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两种化学功能化单壁碳纳米管诱导的星形胶质细胞形态和增殖变化由胶质纤维酸性蛋白差异介导。

Changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic protein.

作者信息

Gottipati Manoj K, Bekyarova Elena, Brenner Michael, Haddon Robert C, Parpura Vladimir

机构信息

Department of Neurobiology, University of Alabama , Birmingham, Alabama 35294, United States.

出版信息

Nano Lett. 2014 Jul 9;14(7):3720-7. doi: 10.1021/nl4048114. Epub 2014 Jun 6.

DOI:10.1021/nl4048114
PMID:24875845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4091642/
Abstract

Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used astrocytes isolated from GFAP null mice. We find that selected astrocytic changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape, and cell death for solutes, and proliferation for films.

摘要

胶质纤维酸性蛋白（GFAP）水平的改变伴随着由胶体溶质和碳纳米管（CNT）薄膜诱导的星形胶质细胞形态和增殖的变化。为了确定GFAP是否是CNT对星形胶质细胞产生影响所必需的，我们使用了从GFAP基因敲除小鼠中分离出的星形胶质细胞。我们发现，CNT诱导的特定星形胶质细胞变化是由GFAP介导的，即对于溶质而言，是周长、形状和细胞死亡；对于薄膜而言，是增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/ac05ab994e12/nl-2013-048114_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/6b7c17fff138/nl-2013-048114_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/fb59b22afcb6/nl-2013-048114_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/80404201cbdd/nl-2013-048114_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/ac05ab994e12/nl-2013-048114_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/6b7c17fff138/nl-2013-048114_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/fb59b22afcb6/nl-2013-048114_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/80404201cbdd/nl-2013-048114_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ad/4091642/ac05ab994e12/nl-2013-048114_0004.jpg

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