NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway; Department of Psychology, University of Oslo, Norway.
NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway.
Psychiatry Res. 2017 Mar;249:286-292. doi: 10.1016/j.psychres.2016.12.048. Epub 2016 Dec 31.
Neurocognitive impairment has been found to be a marked feature in bipolar disorder (BD), also in the early phase of the illness. The longitudinal course of neurocognitive functioning, however, remains sparsely investigated. The aims of the study were to investigate the course of neurocognitive function in BD I, and to what degree neurocognitive change or stability is observed also on the individual level. Forty-two patients and 153 comparable healthy controls were assessed at baseline and one-year follow-up. Compared to the healthy control (HC) group BD I patients perform significantly poorer at both baseline and follow-up across all neurocognitive domains and on most neurocognitive subtests. Neurocognitive impairment remained stable for most patients from baseline to follow-up, both on a group level and when investigating individual trajectories, indicative of a relatively stable course of neurocognitive functioning in the early phase of BD I.
神经认知障碍已被发现是双相情感障碍（BD）的一个显著特征，即使在疾病的早期阶段也是如此。然而，神经认知功能的纵向病程仍很少被研究。本研究的目的是调查 BD I 患者的神经认知功能的病程，以及在个体水平上观察到的神经认知变化或稳定性的程度。42 名患者和 153 名可比的健康对照组在基线和一年随访时进行了评估。与健康对照组（HC）相比，BD I 患者在所有神经认知领域和大多数神经认知子测试中，无论是在基线还是随访时，表现都明显较差。神经认知障碍在大多数患者中从基线到随访都保持稳定，无论是在群体水平还是在研究个体轨迹时，这表明在 BD I 的早期阶段，神经认知功能的病程相对稳定。
