运动可以减轻导致重度抑郁和自杀意念的遗传风险因素。
A genetic risk factor for major depression and suicidal ideation is mitigated by physical activity.
机构信息
Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA; School of Exercise and Nutritional Sciences, San Diego State University, ENS Building, Room 351, 5500 Campanile Drive, San Diego, CA 92182, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California, USA, Irvine, CA 92697, USA.
Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106-3521, USA.
出版信息
Psychiatry Res. 2017 Mar;249:304-306. doi: 10.1016/j.psychres.2017.01.002. Epub 2017 Jan 20.
We evaluated associations of five candidate polymorphisms (Bcl1 [rs41423247], -2C/G [rs2070951], COMT [rs737865], Val66Met [rs6265], and 5HTTLPR [biallelic and triallelic [5HTTLPR/rs25531]) with probable MDD and suicidal ideation (SI), the effects of physical activity on these endpoints, and whether physical activity attenuates genetic risk in military members (N=736). C carriers who were also less physically active were 3.3 times as likely to meet criteria for probable MDD and 9.6 times as likely to endorse SI as compared to physically active GG carriers. An adequate dose of physical activity diminishes risk of MDD and SI imposed by a genetic predisposition.
我们评估了五个候选基因多态性（Bcl1 [rs41423247]、-2C/G [rs2070951]、COMT [rs737865]、Val66Met [rs6265] 和 5HTTLPR [双等位基因和三等位基因 [5HTTLPR/rs25531]）与可能的 MDD 和自杀意念（SI）之间的关联，以及身体活动对这些终点的影响，以及身体活动是否能减轻军事人员的遗传风险（N=736）。与活跃的 GG 携带者相比，不活跃的 CC 携带者符合可能的 MDD 标准的可能性高 3.3 倍，并且表示有 SI 的可能性高 9.6 倍。足够剂量的身体活动可以降低遗传易感性导致的 MDD 和 SI 的风险。
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