Brock Clifton O, Govindappagari Shravya, Gyamfi-Bannerman Cynthia
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.
Am J Perinatol. 2017 Jul;34(8):765-773. doi: 10.1055/s-0037-1598080. Epub 2017 Jan 31.
The objective of this study is to determine the maternal and neonatal morbidity associated with attempting operative vaginal delivery (OVD) compared with the alternative of a laboring repeat cesarean delivery (LRCD) in women attempting a trial of labor after cesarean delivery (TOLAC). This is a secondary analysis of a multicenter prospective study designed to assess perinatal outcomes of OVD in women with a prior uterine scar. The study includes women who attempted TOLAC and reached +2 station with a fully dilated cervix. Composites on neonatal and maternal morbidity were compared between women in whom OVD was attempted and those who underwent LRCD by fitting multivariate logistic regression models. In total, 6,489 women attempting TOLAC reached 2+ station with a fully dilated cervix. Of these, 5,640 (86.9%) had a spontaneous vaginal delivery, 762 (11.7%) underwent attempted OVD, and 87 (1.3%) had an LRCD. Compared with attempting OVD, LRCD was associated with greater neonatal morbidity (odds ratio [OR]: 2.41; 95% confidence interval [CI]: 1.13-5.15) and less maternal morbidity (OR: 0.28; 95% CI: 0.14-0.55). Maternal morbidity of OVD is driven by perineal injury. In laboring women with a previous uterine scar, attempting OVD is associated with greater maternal and less neonatal morbidity than LRCD.
本研究的目的是确定在剖宫产术后试产(TOLAC)的女性中,与尝试经阴道手术分娩(OVD)相比,选择再次剖宫产分娩(LRCD)时的母婴发病率。 这是一项多中心前瞻性研究的二次分析,该研究旨在评估有子宫瘢痕史女性经阴道手术分娩的围产期结局。该研究纳入了尝试TOLAC且宫颈完全扩张至+2坐骨棘水平的女性。通过拟合多变量逻辑回归模型,比较了尝试OVD的女性和接受LRCD的女性在新生儿和母亲发病率方面的综合情况。 总共有6489名尝试TOLAC的女性宫颈完全扩张至+2坐骨棘水平。其中,5640名(86.9%)自然阴道分娩,762名(11.7%)尝试经阴道手术分娩,87名(1.3%)接受再次剖宫产分娩。与尝试经阴道手术分娩相比,再次剖宫产分娩与更高的新生儿发病率相关(比值比[OR]:2.41;95%置信区间[CI]:1.13 - 5.15),而母亲发病率更低(OR:0.28;95%CI:0.14 - 0.55)。经阴道手术分娩的母亲发病率主要由会阴损伤导致。 在有子宫瘢痕史的分娩女性中,与再次剖宫产分娩相比,尝试经阴道手术分娩与更高的母亲发病率和更低的新生儿发病率相关。