通过钯催化的双重氧化环化反应简便合成吲哚并[3,2-]咔唑。
Facile synthesis of indolo[3,2-]carbazoles via Pd-catalyzed twofold oxidative cyclization.
作者信息
Yang Chao, Lin Kai, Huang Lan, Pan Wei-Dong, Liu Sheng
机构信息
Guizhou University, Guiyang, PR China.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang, PR China.
出版信息
Beilstein J Org Chem. 2016 Nov 22;12:2490-2494. doi: 10.3762/bjoc.12.243. eCollection 2016.
A rapid and efficient route has been developed for the synthesis of 9-methoxycarbonylindolo[3,2-]carbazole derivatives. The key steps in this approach involved an aromatic amination and an oxidative biaryl coupling. Via the present route, indolo[3,2-]carbazole derivatives are available in 3-4 steps based on commercially available starting materials.
已经开发出一种快速有效的路线来合成9-甲氧基羰基吲哚并[3,2-]咔唑衍生物。该方法的关键步骤包括芳基胺化和氧化联芳基偶联。通过本路线，基于市售起始原料，吲哚并[3,2-]咔唑衍生物可在3-4步中得到。
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