来自锚链海绵属物种的异常氨基磺酸酯吲哚和一种新型吲哚并[3,2-a]咔唑

Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp.

作者信息

Meragelman Karina M, West Lyndon M, Northcote Peter T, Pannell Lewis K, McKee Tawnya C, Boyd Michael R

机构信息

Molecular Targets Drug Discovery Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702-1201, USA.

出版信息

J Org Chem. 2002 Sep 20;67(19):6671-7. doi: 10.1021/jo020120k.

DOI:10.1021/jo020120k

PMID:12227796

Abstract

Four new indoles, ancorinolates A-C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV-inhibitory activity in the XTT-based, anticytopathicity assay.

摘要

从海绵Ancorina sp.的水提取物中分离出四种新的吲哚类化合物，即锚定醇A - C和双锚定醇B，它们含有氨基磺酸酯和硫酸酯基团。此外，从新西兰两个不同地点采集的Ancorina sp.中还分离出了吲哚并[3,2 - a]咔唑类化合物锚定唑，其也含有氨基磺酸酯和硫酸酯基团。锚定唑是首个被描述为天然产物的吲哚并[3,2 - a]咔唑。在基于XTT的抗细胞病变试验中，锚定醇A（1）和C（3）显示出较弱的HIV抑制活性。