Takahashi Masahiro, Hosomichi Kazuyoshi, Yamaguchi Tetsutaro, Yano Keisuke, Funatsu Takahiro, Adel Mohamed, Haga Shugo, Maki Koutaro, Tajima Atsushi
Department of Orthodontics, School of Dentistry, Showa University , Tokyo, Japan.
Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University , Ishikawa, Japan.
Hum Genome Var. 2017 Jan 26;4:16046. doi: 10.1038/hgv.2016.46. eCollection 2017.
A common disorder of human dentition is the existence of supernumerary teeth. Impacted supernumerary teeth occur most frequently in the maxillary incisor area and are termed mesiodens. We conducted whole-exome sequencing of non-syndromic Japanese individuals possessing supernumerary teeth to identify genes and/or loci involved in the pathogenesis of the condition.
人类牙列的一种常见病症是多生牙的存在。阻生多生牙最常发生在上颌切牙区，被称为正中牙。我们对患有多生牙的非综合征日本个体进行了全外显子组测序，以确定与该病症发病机制相关的基因和/或基因座。
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