Kuda Yuhichi, Shibamoto Toshishige, Zhang Tao, Yang Wei, Tanida Mamoru, Kurata Yasutaka
Department of Physiology II, Kanazawa Medical University, Uchinada, Kahoku-gun, Ishikawa, 920-0293, Japan.
Department of Colorectal and Hernia Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.
J Physiol Sci. 2018 May;68(3):253-260. doi: 10.1007/s12576-017-0527-y. Epub 2017 Jan 31.
Anaphylactic shock is life-threatening, but pathophysiology of the stomach lesion remains unclear. We determined gastric hemodynamics and gastric functions during anaphylactic hypotension, as compared to hypotension induced by hemorrhage or sodium nitroprusside (SNP) in anesthetized and ovalbumin-sensitized Sprague-Dawley rats. Systemic arterial pressure, portal venous pressure, and gastric arterial blood flow were measured, and gastric vascular resistance (GVR) was determined. Separately, the intragastric pressure (IGP) and gastric effluent, as a measure of gastric flux, were continuously measured. During anaphylaxis, GVR decreased only transiently at 0.5 min, followed by an increase. IGP increased markedly, while gastric flux decreased. During hemorrhage, GVR and IGP increased, while gastric flux did not change. When SNP was injected, both GVR and IGP decreased and gastric flux increased only just after injection. In conclusion, gastric vasodilatation occurs only transiently after antigen injection, and gastric motility increases, but gastric emptying deceases during anaphylactic hypotension in anesthetized rats.
过敏性休克危及生命,但胃部病变的病理生理学仍不清楚。我们测定了麻醉且对卵清蛋白致敏的Sprague-Dawley大鼠在过敏性低血压期间的胃血流动力学和胃功能,并与出血或硝普钠(SNP)诱导的低血压进行了比较。测量了体循环动脉压、门静脉压和胃动脉血流量,并测定了胃血管阻力(GVR)。另外,连续测量胃内压(IGP)和作为胃通量指标的胃流出量。在过敏反应期间,GVR仅在0.5分钟时短暂下降,随后升高。IGP显著升高,而胃通量下降。在出血期间,GVR和IGP升高,而胃通量没有变化。注射SNP时,GVR和IGP均下降,且仅在注射后胃通量增加。总之,在麻醉大鼠过敏性低血压期间抗原注射后胃血管扩张仅短暂发生,胃动力增加,但胃排空减少。