Department of Physiology II, Kanazawa Medical University, Uchinada, 920-0293, Japan.
Department of Colorectal and Hernia Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.
J Physiol Sci. 2019 Nov;69(6):953-960. doi: 10.1007/s12576-019-00710-8. Epub 2019 Sep 21.
Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic motility and expulsion by measuring the intracolonic pressure (ICP) and expelled fluid weight in anesthetized rats during anaphylactic hypotension. Substantial systemic hypotension occurred in every sensitized rat after antigen injection. One min after antigen injection, ICP began to increase and remained elevated for 5 min, which was revealed to represent tonic contraction by the video-recording procedure, and was accompanied by increased colonic fluid expulsion. Parasympathectomy composed of subdiaphragmatic vagotomy combined with pelvic nerve transection reduced the duration of the tonic contraction, but not expelled colonic fluid. Furthermore, denervation of afferent parasympathetic nerves produced essentially the same effect as parasympathectomy. Sympathectomy did not significantly change any parameters. In conclusion, the colonic motility during anaphylactic hypotension is characterized by 5-min lasting tonic contraction which is associated with increased colonic fluid expulsion and is involved by parasympathetic nerves, especially their afferents, but not sympathetic nerves, in anesthetized rats.
腹泻是一种与全身性过敏反应相关的胃肠道症状，可能由结肠蠕动增加引起。我们通过测量麻醉大鼠在过敏低血压期间的腔内压力（ICP）和排出的液体重量来确定结肠蠕动和排出。在抗原注射后，每个致敏大鼠都出现了明显的全身性低血压。抗原注射后 1 分钟，ICP 开始增加，并持续升高 5 分钟，这通过录像过程显示为紧张性收缩，并伴有结肠液体排出增加。由膈下迷走神经切断术和骨盆神经切断术组成的副交感神经切除术减少了紧张性收缩的持续时间，但没有排出结肠液体。此外，传入副交感神经的去神经作用产生的效果与副交感神经切除术基本相同。交感神经切除术对任何参数均无显著影响。总之，在过敏性低血压期间，结肠运动的特征是持续 5 分钟的紧张性收缩，与增加的结肠液体排出有关，并涉及副交感神经，特别是其传入神经，但不涉及交感神经，在麻醉大鼠中。
