Use of defibrotide in the treatment of acute myocardial infarction.

作者信息

Milazzotto F, Carelli M, Citone C, Di Marcotullio G, Giampaolo P, Malinconico U, Polizzi C, Tubaro M, Giovannini E, Boccardi L

机构信息

Coronary Care Unit, Echocardiography Service, S. Camillo Hospital, Rome, Italy.

出版信息

Semin Thromb Hemost. 1989 Oct;15(4):464-9. doi: 10.1055/s-2007-1002745.

The results of this preliminary clinical trial confirm the thrombolytic effect of defibrotide demonstrated in preclinical models; demonstrate the positive influence of the product on the natural history of early AMI; suggest that the optimal dosage range should include not less than 1.6 gm of defibrotide during the first hour of treatment; and justify further commitment in the study of defibrotide also beyond the scope of treating AMI.