Belem da Silva Cristiano Tschiedel, Costa Marianna de Abreu, Bortoluzzi Andressa, Pfaffenseller Bianca, Vedana Flávia, Kapczinski Flávio, Manfro Gisele Gus
From the Federal University of Rio Grande do Sul (Belem da Silva, Costa, Bortoluzzi, Vedana, Kapczinski, Manfro), Brazil; Hospital de Clínicas de Porto Alegre (Belem da Silva, Costa, Bortoluzzi, Pfaffenseller, Vedana, Kapczinski, Manfro), Brazil; Basic Research and Advanced Investigations in Neurosciences (Bortoluzzi, Manfro), BRAIN Laboratory, HCPA; and Laboratório de Psiquiatria Molecular (Pfaffenseller, Kapczinski), Instituto Nacional de Ciência e Tecnologia-Translacional em Medicina (INCT), HCPA, UFRGS.
Psychosom Med. 2017 Feb/Mar;79(2):126-132. doi: 10.1097/PSY.0000000000000384.
Several studies have investigated possible biological correlates of mental disorders. Although some studies have consistently reported elevated levels of serum inflammatory markers in depression, very few have evaluated cytokine levels in patients with lifetime panic disorder (PD).
Seventy-eight adults (75% women) from an anxiety disorders outpatient unit were categorized according to their PD status: current or in remission. Serum levels of interleukin (IL)-6, tumor necrosis factor α, and IL-10 were evaluated using flow cytometry with enhanced sensitivity flex sets. Data on clinical comorbidity, lipid profile, fasting blood glucose, C-reactive protein, and PD severity were also obtained.
Significantly higher mean levels of serum IL-6 (0.83 vs 0.60 pg/mL [95% confidence interval {CI}for the log-transformed mean difference, -0.41 to -0.57], p = .008) but not of tumor necrosis factor-α (0.18 vs 0.14 pg/mL [95% CI, -1.12 to 0.11]; p = 0.53) or IL-10 (0.21 vs 0.26 [95% CI, -0.20 to 0.44]; p = 0.16), were associated with current PD compared to remitted PD. Higher Panic Disorder Severity Scale (standardized β = 0.36; p = .013), body mass index (standardized β = 0.53, p < .001) and fasting blood glucose 5.6 mmol/L or greater (standardized β = 0.23, p = .038) were significantly associated with higher levels of IL-6 in the multivariate linear regression model.
Our findings support a proinflammatory state in patients with current PD that is independent of possible confounders. Although there are important implications of these findings, replication is required.
多项研究探讨了精神障碍可能的生物学关联。尽管一些研究一直报告抑郁症患者血清炎症标志物水平升高，但很少有研究评估终生惊恐障碍（PD）患者的细胞因子水平。
将焦虑症门诊的78名成年人（75%为女性）根据其PD状态进行分类：当前患病或已缓解。使用具有增强灵敏度的flex套装通过流式细胞术评估血清白细胞介素（IL）-6、肿瘤坏死因子α和IL-10水平。还获取了临床共病、血脂谱、空腹血糖、C反应蛋白和PD严重程度的数据。
与缓解期PD相比，当前PD患者血清IL-6的平均水平显著更高（0.83对0.60 pg/mL[对数转换后平均差异的95%置信区间{CI}，-0.41至-0.57]，p = 0.008），但肿瘤坏死因子-α（0.18对0.14 pg/mL[95%CI，-1.12至0.11]；p = 0.53）或IL-10（0.21对0.26[95%CI，-0.20至0.44]；p = 0.16）并非如此。在多变量线性回归模型中，较高的惊恐障碍严重程度量表（标准化β = 0.36；p = 0.013）、体重指数（标准化β = 0.53，p < 0.001）和空腹血糖5.6 mmol/L或更高（标准化β = 0.23，p = 0.038）与IL-6水平升高显著相关。
我们的研究结果支持当前PD患者存在一种独立于可能混杂因素的促炎状态。尽管这些发现具有重要意义，但仍需要重复验证。
