Abuş Sabri, Kapıcı Yaşar, Ayhan Selçuk, Tekin Atilla
Department of Cardiology, Adıyaman Training and Research Hospital, Adıyaman, Turkey.
Clinic of Psychiatry, Kahta State Hospital, Adıyaman, Turkey.
Psychiatry Clin Psychopharmacol. 2023 Mar 1;33(1):8-13. doi: 10.5152/pcp.2023.22451. eCollection 2023 Mar.
Autonomic instability is blamed for panic disorder pathophysiology. It has been suggested that this may raise the risk of cardiovascular disease. A new proposal for ventricular depolarization and repolarization impairment is the frontal QRS-T angle.
In this cross-sectional study, 61 patients with panic disorder and 73 healthy controls were included. The severity of panic disorder was evaluated using the Severity Measure for Panic Disorder-Adult. Electrocardiography, echocardiography, hemogram, and biochemistry data were recorded.
Patients with panic disorder had a greater frontal QRS-T angle than healthy controls. In panic disorder patients, the values for hemoglobin, eosinophil count, and high-density lipoprotein cholesterol were all significantly lower than healthy controls. In comparison to healthy controls, panic disorder patients had significantly higher values for total cholesterol, fasting triglycerides, low-density lipoprotein cholesterol, platelet-to-lymphocyte ratio, and monocyte-to-high-density lipoprotein cholesterol ratio. Significant correlations were found between frontal QRS-T and Severity Measure for Panic Disorder-Adult, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. The frontal QRS-T value is positively and significantly predicted by the neutrophil-to-lymphocyte ratio value according to the linear regression analysis for the frontal QRS-T angle [(6.54) = 8.375, < .001, adjusted : 0.424].
The current study found that the frontal QRS-T angle increased with the severity of the disease in patients with panic disorder. Frontal QRS-T angle may help to estimate cardiovascular disease risk in patients with panic disorder. This relationship may be necessary in terms of cardiovascular events and inflammatory conditions.
自主神经功能不稳定被认为是惊恐障碍病理生理学的原因。有人提出，这可能会增加心血管疾病的风险。心室去极化和复极化受损的一个新指标是额面QRS-T角。
在这项横断面研究中，纳入了61例惊恐障碍患者和73名健康对照者。使用成人惊恐障碍严重程度量表评估惊恐障碍的严重程度。记录心电图、超声心动图、血常规和生化数据。
惊恐障碍患者的额面QRS-T角大于健康对照者。在惊恐障碍患者中，血红蛋白、嗜酸性粒细胞计数和高密度脂蛋白胆固醇的值均显著低于健康对照者。与健康对照者相比，惊恐障碍患者的总胆固醇、空腹甘油三酯、低密度脂蛋白胆固醇、血小板与淋巴细胞比值和单核细胞与高密度脂蛋白胆固醇比值的值显著更高。在额面QRS-T与成人惊恐障碍严重程度量表、中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值之间发现了显著相关性。根据额面QRS-T角的线性回归分析，中性粒细胞与淋巴细胞比值的值对额面QRS-T值有正向且显著的预测作用[（6.54）=8.375，P<0.001，调整后R²：0.424]。
当前研究发现，惊恐障碍患者的额面QRS-T角随疾病严重程度增加。额面QRS-T角可能有助于评估惊恐障碍患者的心血管疾病风险。就心血管事件和炎症状况而言，这种关系可能是必要的。
