Schargus M, Geerling G, Joachim S C
Augenklinik Schweinfurt-Gerolzhofen.
Augenklinik, Universitätsklinikum Düsseldorf.
Klin Monbl Augenheilkd. 2018 May;235(5):597-602. doi: 10.1055/s-0042-121424. Epub 2017 Feb 1.
Dry eye disease is one of the most common diagnoses in ophthalmology. A variety of subjective and objective test methods with imprecise limits and highly different sensitivities and specificities complicate the diagnosis. Especially mild to moderate pathological findings can be misdiagnosed. In recent years, new options have opened, through the development of new, clinical practicable diagnostic equipment, for example, for the analysis of tear film osmolarity or matrix metalloproteinases (MMP-9). The value of tear film osmolarity and determination of MMP-9 levels in the diagnosis of dry eye and its subtypes will be discussed and evaluated objectively, on the basis of published study results.
干眼症是眼科最常见的诊断之一。各种主观和客观测试方法的界限不精确，灵敏度和特异性差异很大，这使得诊断变得复杂。尤其是轻度至中度的病理结果可能会被误诊。近年来，通过开发新的、临床可行的诊断设备，例如用于分析泪膜渗透压或基质金属蛋白酶（MMP-9），出现了新的诊断选择。本文将根据已发表的研究结果，客观地讨论和评估泪膜渗透压值以及MMP-9水平测定在干眼症及其亚型诊断中的价值。
