Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17014, Korea.
BMB Rep. 2017 Apr;50(4):214-219. doi: 10.5483/bmbrep.2017.50.4.006.
Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression. [BMB Reports 2017; 50(4): 214-219].
线粒体在 ATP 生成、细胞凋亡和活性氧产生中发挥关键作用。尽管线粒体形态的动态调节是维持细胞内稳态的关键步骤，但调节机制尚不完全清楚。在这项研究中，我们发现 miR-200a-3p 通过靶向线粒体分裂因子（MFF）成为线粒体动力学的一个新的调节因子。我们证明了 miR-200a-3p 的异位表达增强了线粒体的延伸、线粒体 ATP 合成、线粒体膜电位和耗氧量。这些结果表明 miR-200a-3p 通过下调 MFF 的表达正向调节线粒体的延伸。[BMB 报告 2017; 50(4): 214-219]。
