Ilangovan Vijaysundar, Vivakaran Thanga Tirupathi Rajan, Gunasekaran D, Devikala D
Department of Neurosurgery, Saveetha Medical College and Hospital, Kanchipuram, Tamil Nadu, India.
Department of Anaesthesiology, Saveetha Medical College and Hospital, Kanchipuram, Tamil Nadu, India.
J Neurosci Rural Pract. 2017 Jan-Mar;8(1):55-59. doi: 10.4103/0976-3147.193535.
This was a prospective analysis of epidural tramadol as a single analgesic agent delivered through intraoperatively placed epidural catheter for postoperative pain relief after spinal fusion procedures in terms of efficacy and cost.
Twenty patients who underwent spinal fusion procedures were included in the study. After completion of the procedure, an epidural catheter was placed at the highest level of exposed dura and brought out through a separate tract. Postoperatively, tramadol was infused into the epidural space via the catheter at a dose of 1 mg/kg diluted in 10 ml of saline. The dosage frequency was arbitrarily fixed at every 6 h during the first 2 days and thereafter reduced to every 8 h after the first 2 days till day 5. Conventional intravenous analgesics were used only if additional analgesia was required as assessed by visual analog scale (VAS).
Patients' VAS score was assessed every 4 h from the day of surgery. Patients with a VAS score of 6 or more were given additional analgesia in the form of intravenous paracetamol. Of the twenty patients, eight patients needed additional analgesia during the first 24 h and none required additional analgesia after the first 24 h. The median VAS score was 7 within the first 24 h and progressively declined thereafter. Epidural tramadol was noted to be many times cheaper than conventional parenteral analgesics.
Epidural tramadol infusion is safe and effective as a standalone analgesic after open spinal fusion surgery, especially after the 1 postoperative day. Intraoperative placement of the epidural catheter is a simple way of delivering tramadol to the epidural space. The cost of analgesia after spinal fusion surgery can be reduced significantly using epidural tramadol alone.
本研究旨在对硬膜外注射曲马多作为单一镇痛剂通过术中放置的硬膜外导管用于脊柱融合术后疼痛缓解的疗效和成本进行前瞻性分析。
本研究纳入了20例行脊柱融合术的患者。手术结束后,在暴露硬膜的最高水平放置一根硬膜外导管,并通过一个单独的通道引出。术后,将曲马多以1mg/kg的剂量稀释于10ml生理盐水中,经导管注入硬膜外间隙。给药频率在前2天任意固定为每6小时一次,此后在前2天后减至每8小时一次,直至第5天。仅在通过视觉模拟量表(VAS)评估需要额外镇痛时才使用传统静脉镇痛剂。
自手术日起每4小时评估患者的VAS评分。VAS评分≥6分的患者给予静脉注射对乙酰氨基酚形式的额外镇痛。20例患者中,8例在术后24小时内需要额外镇痛,术后24小时后均无需额外镇痛。术后24小时内VAS评分中位数为7分,此后逐渐下降。结果表明,硬膜外注射曲马多比传统胃肠外给药镇痛剂便宜很多倍。
硬膜外注射曲马多作为开放性脊柱融合术后的单一镇痛剂是安全有效的,尤其是在术后第1天之后。术中放置硬膜外导管是将曲马多输送至硬膜外间隙的一种简单方法。单独使用硬膜外曲马多可显著降低脊柱融合术后的镇痛成本。