代谢组学标准化进展及其在未来临床检验医学中的意义
Progress in Metabolomics Standardisation and its Significance in Future Clinical Laboratory Medicine.
作者信息
Dias Daniel A, Koal Therese
机构信息
School of Health and Biomedical Sciences, Discipline of Laboratory Medicine, RMIT University , Victoria, Australia.
Biocrates Life Sciences AG , Eduard-Bodem-Gasse 8, 6020 Innsbruck, Austria.
出版信息
EJIFCC. 2016 Dec 1;27(4):331-343. eCollection 2016 Dec.
Abstract
Today, the technology of 'targeted' based metabolomics is pivotal in the clinical analysis workflow as it provides information of metabolic phenotyping (metabotypes) by enhancing our understanding of metabolism of complex diseases, biomarker discovery for disease development, progression, treatment, and drug function and assessment. This review is focused on surveying and providing a gap analysis on metabolic phenotyping with a focus on targeted based metabolomics from an instrumental, technical discussing the instrumentation, pre- to post- analytical aspects as well as an overall future necessity for biomarker discovery and future (pre-) clinical routine application.
摘要
如今，基于“靶向”的代谢组学技术在临床分析工作流程中至关重要，因为它通过加深我们对复杂疾病代谢的理解、发现疾病发展、进展、治疗和药物功能及评估的生物标志物，提供代谢表型（代谢型）信息。本综述着重于对代谢表型进行调查并提供差距分析，重点关注基于靶向的代谢组学，从仪器、技术方面讨论仪器设备、分析前到分析后的各个方面，以及生物标志物发现和未来（临床前）临床常规应用的总体未来必要性。
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