冠心病患者中非酒精性脂肪性肝病的患病率。
Prevalence of non-alcoholic fatty liver disease in patients with coronary artery disease.
作者信息
Baharvand-Ahmadi Babak, Sharifi Khalil, Namdari Mehrdad
机构信息
Associate Professor, Khorramabad Heart Center AND Department of Cardiology, Shahid Madani Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.
Assistant Professor, Lorestan University of Medical Sciences, Khorramabad, Iran.
出版信息
ARYA Atheroscler. 2016 Jul;12(4):201-205.
BACKGROUND
Several common metabolic risk factors contribute to development of both non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD). The aim was to determine prevalence of NAFLD in patients with CAD.
METHODS
This prospective study was carried out from December 2011 to June 2012. All patients with documented diagnosis of CAD with stenosis of one of the main coronary arteries or their branches were included in the study. Ultrasound examination of liver was performed in all patients to diagnose hepatic steatosis. Accordingly, the severity of steatosis was graded from 0 (absence of steatosis) to 3 (severe steatosis). Finally, prevalence of NAFLD was determined in the studied patients.
RESULTS
Among 170 patients with CAD included in the study, 63 and 17 had grade 1 and 2 hepatic steatosis in ultrasound examination, respectively, providing prevalence of 47% in studied population. There was no significant difference between patients with NAFLD and those without NAFLD regarding gender (P = 0.120), presence of diabetes mellitus (P = 0.270), hyperlipidemia (P = 0.210) and hypertension (P = 0.870). There was no association between involvement of left anterior descending artery and hepatic steatosis (P = 0.870).
CONCLUSION
The present study indicated a high prevalence of NAFLD in patients with documented CAD.
背景
几种常见的代谢危险因素会导致非酒精性脂肪性肝病（NAFLD）和冠状动脉疾病（CAD）的发生。本研究旨在确定CAD患者中NAFLD的患病率。
方法
本前瞻性研究于2011年12月至2012年6月进行。所有经记录诊断为CAD且主要冠状动脉及其分支之一存在狭窄的患者均纳入本研究。对所有患者进行肝脏超声检查以诊断肝脂肪变性。据此，将脂肪变性的严重程度从0（无脂肪变性）分级到3（严重脂肪变性）。最后，确定所研究患者中NAFLD的患病率。
结果
在纳入研究的170例CAD患者中，超声检查分别有63例和17例存在1级和2级肝脂肪变性，在所研究人群中的患病率为47%。NAFLD患者和非NAFLD患者在性别（P = 0.120）、糖尿病（P = 0.270）、高脂血症（P = 0.210）和高血压（P = 0.870）方面无显著差异。左前降支受累与肝脂肪变性之间无关联（P = 0.870）。
结论
本研究表明，经记录诊断为CAD的患者中NAFLD的患病率较高。
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