Schweiger Martin, Knirsch Walter, Cesarovic Niko, Krüger Bernard, Schmiady Martin, Frauenfelder Thomas, Frese Laura, Dave Hitendu, Hoerstrup Simon Philipp, Hübler Michael
Department of Congenital Cardiovascular Surgery, Paediatric Heart Center, University Children's Hospital, Zurich, Switzerland.
Division of Pediatric Cardiology, Paediatric Heart Center, University Children's Hospital Zurich, Zurich, Switzerland.
J Thorac Dis. 2016 Dec;8(12):3733-3738. doi: 10.21037/jtd.2016.12.72.
To overcome current limitations of valve substitutes and tissue substitutes the technology of tissue engineering (TE) continues to offer new perspectives in congenital cardiac surgery. We report our experiences and results implanting a decellularized TE patch in nine sheep in orthotropic position as aortic valve leaflet substitute. Establishing the animal model, feasibility, cardiopulmonary bypass issues and operative technique are highlighted.
为克服目前瓣膜替代物和组织替代物的局限性,组织工程(TE)技术继续为先天性心脏手术提供新的前景。我们报告了将脱细胞组织工程补片作为主动脉瓣叶替代物原位植入9只绵羊体内的经验和结果。重点介绍了动物模型的建立、可行性、体外循环问题及手术技术。