绵羊（Ovis aries）作为体外循环术前、术中和术后心血管手术及管理的模型。
Sheep (Ovis aries) as a model for cardiovascular surgery and management before, during, and after cardiopulmonary bypass.
作者信息
DiVincenti Louis, Westcott Robin, Lee Candice
机构信息
Department of Comparative Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Division of Laboratory Animal Medicine, University of Rochester Medical Center, Rochester, New York, USA.
出版信息
J Am Assoc Lab Anim Sci. 2014 Sep;53(5):439-48.
Abstract
Because of its similarity to humans in important respects, sheep (Ovis aries) are a common animal model for translational research in cardiovascular surgery. However, some unique aspects of sheep anatomy and physiology present challenges to its use in these complicated experiments. In this review, we discuss relevant anatomy and physiology of sheep and discuss management before, during, and after procedures requiring cardiopulmonary bypass to provide a concise source of information for veterinarians, technicians, and researchers developing and implementing protocols with this model.
摘要
由于绵羊（Ovis aries）在重要方面与人类相似，因此它是心血管外科转化研究中常用的动物模型。然而，绵羊解剖学和生理学的一些独特方面给在这些复杂实验中使用它带来了挑战。在这篇综述中，我们讨论了绵羊的相关解剖学和生理学，并讨论了在需要体外循环的手术前、手术中和手术后的管理，为兽医、技术人员以及开发和实施该模型方案的研究人员提供一个简洁的信息来源。
相似文献
1
Sheep (Ovis aries) as a model for cardiovascular surgery and management before, during, and after cardiopulmonary bypass.绵羊（Ovis aries）作为体外循环术前、术中和术后心血管手术及管理的模型。
J Am Assoc Lab Anim Sci. 2014 Sep;53(5):439-48.
2
Sheep (Ovis aries) as a model for cardiovascular surgery and management before, during, and after cardiopulmonary bypass.绵羊（Ovis aries）作为体外循环前、中、后心血管手术及管理的模型。
J Am Assoc Lab Anim Sci. 2015 Jan;54(1):7-8.
3
Response to Dr Katz's letter to the editor.对卡茨博士致编辑信的回复。
J Am Assoc Lab Anim Sci. 2015 Jan;54(1):8-9.
4
Renal hemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep under total intravenous anesthesia.在绵羊全身静脉麻醉下进行实验性心肺转流期间的肾脏血液动力学和氧合作用。
Am J Physiol Regul Integr Comp Physiol. 2020 Feb 1;318(2):R206-R213. doi: 10.1152/ajpregu.00290.2019. Epub 2019 Dec 11.
5
Neuroprotective Anesthesia Regimen and Intensive Management for Pediatric Cardiac Surgery with Cardiopulmonary Bypass: a Review and Initial Experience.体外循环下小儿心脏手术的神经保护麻醉方案与强化管理：综述与初步经验
Braz J Cardiovasc Surg. 2017 Nov-Dec;32(6):523-529. doi: 10.21470/1678-9741-2016-0064.
6
[Contribution to the macroscopic anatomy of the portal veins in sheep (Ovis aries)].
Anat Anz. 1962 Jan 31;110:312-26.
7
[THE ATRIO-VENTRICULAR CONNECTIONS IN THE HEARTS OF OVIS ARIES, CAPRA HIRCUS, BOS TAURUS AND EQUUS CABALLUS].[绵羊、山羊、牛和马心脏中的房室连接]
Biol Lat. 1964 Apr-Jun;17:113-44.
8
9
10
The complete mitochondrial genome of domestic sheep, Ovis aries.家羊（Ovis aries）的完整线粒体基因组。
Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27(2):1425-7. doi: 10.3109/19401736.2014.953076. Epub 2014 Aug 27.
引用本文的文献
1
Short- and Medium-Term Surgical Outcomes of Tissue-Engineered Pulmonary Valve Replacement in Sheep.绵羊组织工程肺动脉瓣置换术的短期和中期手术结果
Tissue Eng Regen Med. 2025 Jul 7. doi: 10.1007/s13770-025-00735-8.
2
Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts.超大尺寸导管可预测组织工程血管移植物中的狭窄。
JACC Basic Transl Sci. 2025 Jul;10(7):101248. doi: 10.1016/j.jacbts.2025.02.008. Epub 2025 Apr 16.
3
Passive biaxial mechanical properties of sheep myocardium.绵羊心肌的被动双轴力学特性。
Front Bioeng Biotechnol. 2025 Mar 20;13:1549829. doi: 10.3389/fbioe.2025.1549829. eCollection 2025.
4
Animal models of hemorrhage, parameters, and development of hemostatic methods.出血的动物模型、参数及止血方法的发展
Lab Anim Res. 2025 Feb 3;41(1):5. doi: 10.1186/s42826-025-00239-5.
5
Animal Models for Mechanical Circulatory Support: A Research Review.机械循环支持的动物模型：一项研究综述。
Rev Cardiovasc Med. 2024 Sep 29;25(10):351. doi: 10.31083/j.rcm2510351. eCollection 2024 Oct.
6
An ovine septic shock model of live bacterial infusion.活细菌输注的绵羊败血症休克模型。
Intensive Care Med Exp. 2024 Oct 28;12(1):94. doi: 10.1186/s40635-024-00684-x.
7
Dynamic Narrowing of the Diaphragmatic Vena Cava in Ovis aries.绵羊膈下腔静脉动态变窄。
Anat Histol Embryol. 2024 Nov;53(6):e13114. doi: 10.1111/ahe.13114.
8
Combined treatment with vitamin C, hydrocortisone and thiamine does not attenuate morbidity and mortality of septic sheep.维生素C、氢化可的松和硫胺素联合治疗不能减轻脓毒症绵羊的发病率和死亡率。
Lab Anim Res. 2024 Aug 12;40(1):27. doi: 10.1186/s42826-024-00213-7.
9
Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway.缓激肽通过抑制Nrf2-xCT途径在低温循环骤停后诱发急性肾损伤。
iScience. 2024 May 22;27(6):110075. doi: 10.1016/j.isci.2024.110075. eCollection 2024 Jun 21.
10
Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep.妊娠早期至中期睾酮过量会导致产后绵羊出现不良心脏结局。
Am J Physiol Heart Circ Physiol. 2024 Aug 1;327(2):H315-H330. doi: 10.1152/ajpheart.00763.2023. Epub 2024 May 31.
本文引用的文献
1
Review article: heparin sensitivity and resistance: management during cardiopulmonary bypass.综述文章：肝素敏感性和抵抗性：体外循环期间的管理。
Anesth Analg. 2013 Jun;116(6):1210-22. doi: 10.1213/ANE.0b013e31827e4e62. Epub 2013 Feb 13.
2
Effects of retrograde autologous priming on blood transfusion and clinical outcomes in adults: a meta-analysis.逆行自体预充对成人输血及临床结局的影响：一项荟萃分析
Perfusion. 2013 May;28(3):238-43. doi: 10.1177/0267659112474861. Epub 2013 Jan 22.
3
Initial experience with a juvenile sheep model for evaluation of the pediatric intracorporeal ventricular assist devices [corrected].小儿体内心室辅助装置评估的幼年绵羊模型的初步经验 [已更正]。
ASAIO J. 2013 Jan-Feb;59(1):75-80. doi: 10.1097/MAT.0b013e31827986fe.
4
Animal models of mitral regurgitation induced by mitral valve chordae tendineae rupture.二尖瓣腱索断裂所致二尖瓣反流的动物模型。
J Heart Valve Dis. 2012 Jul;21(4):416-23.
5
Clinical review: management of weaning from cardiopulmonary bypass after cardiac surgery.临床综述：心脏手术后体外循环撤机的管理
Ann Card Anaesth. 2012 Jul-Sep;15(3):206-23. doi: 10.4103/0971-9784.97977.
6
The sensitivity of sheep to vecuronium: an example of the limitations of extrapolation.
Can J Anaesth. 2012 Jul;59(7):722-3. doi: 10.1007/s12630-012-9707-7. Epub 2012 Apr 3.
7
Cardioprotection during cardiac surgery.心脏手术中的心肌保护。
Cardiovasc Res. 2012 May 1;94(2):253-65. doi: 10.1093/cvr/cvs131. Epub 2012 Mar 22.
8
Neuromuscular blockade and outcome in cardiac anesthesia.
Ann Card Anaesth. 2010 Sep-Dec;13(3):189-91. doi: 10.4103/0971-9784.69035.
9
Effects of positive end-expiratory pressure on anesthesia-induced atelectasis and gas exchange in anesthetized and mechanically ventilated sheep.呼气末正压对麻醉并机械通气绵羊麻醉诱导肺不张及气体交换的影响
Am J Vet Res. 2010 Aug;71(8):867-74. doi: 10.2460/ajvr.71.8.867.
10
Ventricular restraint therapy for heart failure: the right ventricle is different from the left ventricle.心力衰竭的心室约束治疗：右心室不同于左心室。
J Thorac Cardiovasc Surg. 2010 Apr;139(4):1012-8. doi: 10.1016/j.jtcvs.2009.09.064.
Zotero 插件