DiVincenti Louis, Westcott Robin, Lee Candice
Department of Comparative Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Division of Laboratory Animal Medicine, University of Rochester Medical Center, Rochester, New York, USA.
J Am Assoc Lab Anim Sci. 2014 Sep;53(5):439-48.
Because of its similarity to humans in important respects, sheep (Ovis aries) are a common animal model for translational research in cardiovascular surgery. However, some unique aspects of sheep anatomy and physiology present challenges to its use in these complicated experiments. In this review, we discuss relevant anatomy and physiology of sheep and discuss management before, during, and after procedures requiring cardiopulmonary bypass to provide a concise source of information for veterinarians, technicians, and researchers developing and implementing protocols with this model.
由于绵羊（Ovis aries）在重要方面与人类相似，因此它是心血管外科转化研究中常用的动物模型。然而，绵羊解剖学和生理学的一些独特方面给在这些复杂实验中使用它带来了挑战。在这篇综述中，我们讨论了绵羊的相关解剖学和生理学，并讨论了在需要体外循环的手术前、手术中和手术后的管理，为兽医、技术人员以及开发和实施该模型方案的研究人员提供一个简洁的信息来源。
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