药物与DNA的络合作用是光致敏胸腺嘧啶二聚化的关键因素。
Drug-DNA complexation as the key factor in photosensitized thymine dimerization.
作者信息
Cuquerella M Consuelo, Lhiaubet-Vallet Virginie, Miranda Miguel A, Bosca Francisco
机构信息
Instituto Universitario Mixto de Tecnología Química UPV-CSIC, Universitat Politècnica de València, Avda de los Naranjos, s/n, 46022 Valencia, Spain.
出版信息
Phys Chem Chem Phys. 2017 Feb 15;19(7):4951-4955. doi: 10.1039/c6cp08485k.
The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in combination with in vitro DNA damage assays. This finding opens the door to re-evaluate the mechanisms involved in CPDs photosensitized by other chemicals.
通过飞秒和纳秒瞬态吸收与发射测量以及体外DNA损伤检测，已证明光敏剂@DNA络合在环丁烷嘧啶二聚体（CPD）形成过程中的关键作用。这一发现为重新评估其他化学物质光敏化CPD所涉及的机制打开了大门。
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