Hashimoto Yuki, Uyama Miki, Takada Yuko, Yoshida Kenji, Ishiko Akira
Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
J Dermatol. 2017 May;44(5):538-541. doi: 10.1111/1346-8138.13752. Epub 2017 Feb 2.
Although psoriatic nail lesions are small, they cause considerable discomfort for patients and adversely affect quality of life. Few studies have evaluated the dermoscopic features of psoriatic nails. The aim of this study was to clarify the dermoscopic features of nail psoriasis and identify those that reflect psoriatic activity. During biologic treatment of psoriasis, six patients with psoriatic nails twice underwent dermoscopic examination, with an interval of 17-42 weeks. We used the modified Nail Psoriasis Severity Index score and Psoriasis Area and Severity Index score to identify and assess dermoscopic features. We identified 10 dermoscopic findings, of which disappearance of diffuse scaling of the nail plate, transverse step-like notches and splinter hemorrhages of the nail bed, and appearance of erythematous borders of the onycholytic area were associated with improvement in Psoriasis Area and Severity Index score. Dermoscopy can detect nail changes during psoriasis treatment and should be used to evaluate treatment success.
尽管银屑病甲损害较小，但它们给患者带来了相当大的不适，并对生活质量产生不利影响。很少有研究评估银屑病甲的皮肤镜特征。本研究的目的是阐明银屑病甲的皮肤镜特征，并识别那些反映银屑病活动的特征。在银屑病的生物治疗期间，6例银屑病甲患者接受了两次皮肤镜检查，间隔时间为17 - 42周。我们使用改良的指甲银屑病严重程度指数评分和银屑病面积和严重程度指数评分来识别和评估皮肤镜特征。我们识别出10种皮肤镜表现，其中甲板弥漫性鳞屑消失、甲床横向阶梯状切迹和裂片样出血以及甲分离区红斑边界的出现与银屑病面积和严重程度指数评分的改善相关。皮肤镜可以在银屑病治疗期间检测指甲变化，应用于评估治疗效果。
