Malek D E, Alarie Y
Department of Industrial Environmental Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
Toxicol Appl Pharmacol. 1989 Nov;101(2):340-55. doi: 10.1016/0041-008x(89)90282-2.
A guinea pig ergometer was constructed within an enclosure, with inlet and outlet ports for continuous ventilation, designed so that the enclosure would work as a whole-body plethysmograph as well as an inhalation exposure chamber. This system provided continuous measurement of tidal volume, respiratory frequency, oxygen uptake, and carbon dioxide output which enabled an evaluation of performance in terms of distance traveled over time with the animals running at a known speed and constant oxygen uptake. The effects of CO or HCl in running versus sedentary animals were investigated using this apparatus. For CO, exercise increased the rapidity of the onset of incapacitation as would be predicted by the increase in metabolic rate. HCl produced a more severe incapacitating effect in exercising animals that was out of proportion with the increase in minute volume induced by exercise.
在一个封闭空间内构建了一台豚鼠测力计，设有用于持续通风的进出口，其设计使得该封闭空间既可以作为全身体积描记器，也可以作为吸入暴露室。该系统可连续测量潮气量、呼吸频率、氧气摄取量和二氧化碳排出量，从而能够根据动物以已知速度奔跑且氧气摄取量恒定的情况下随时间行进的距离来评估其性能。使用该装置研究了一氧化碳或氯化氢对奔跑动物和久坐动物的影响。对于一氧化碳，运动如预期的那样因代谢率增加而加快了丧失能力的速度。氯化氢对运动中的动物产生了更严重的致残作用，这与运动引起的分钟通气量增加不成比例。
