Malek D E, Stock M F, Alarie Y
Fundam Appl Toxicol. 1987 Apr;8(3):335-45. doi: 10.1016/0272-0590(87)90083-2.
A new behavioral model has been developed and used to assess the performance of mice during exposure to carbon monoxide, hydrogen chloride, or subambient levels of oxygen. The apparatus is a ventilated 150-ft series of glass tubes forming an S-shaped exposure system. Performance evaluation was obtained for two sublethal responses: distance traveled/time and incapacitation. Performance of normal mice (Type I) or mice previously fitted with a tracheal cannula (Type II) was very reproducible and similar. Concentration-response relationships were obtained showing the deterioration of performance with exposures to CO from 2500 ppm, HCl from 1095 ppm, and below 8.8% ambient O2 level. This model is likely to be sensitive to other asphyxiants and irritants. It includes both distance traveled and time of performance prior to incapacitation. Both are critical parameters to be included in escape hazard analysis in fire situations and possibly in other accidents involving chemical spills.
一种新的行为模型已被开发出来，并用于评估小鼠在接触一氧化碳、氯化氢或低于环境水平的氧气时的表现。该装置是一个通风的150英尺长的玻璃管系列，形成一个S形暴露系统。针对两种亚致死反应进行了性能评估：行进距离/时间和失能。正常小鼠（I型）或先前安装了气管插管的小鼠（II型）的表现具有很高的重复性且相似。获得了浓度-反应关系，表明暴露于2500 ppm的一氧化碳、1095 ppm的氯化氢以及低于8.8%的环境氧气水平时，性能会下降。该模型可能对其他窒息剂和刺激物敏感。它包括行进距离和失能前的表现时间。这两个都是火灾情况下逃生危险分析以及可能涉及化学泄漏的其他事故中需要纳入的关键参数。
