Webber Troy A, Soder Heather E, Potts Geoffrey F, Park Jong Y, Bornovalova Marina A
Department of Psychology, University of South Florida.
Department of Cancer Epidemiology, Moffitt Cancer Center.
Exp Clin Psychopharmacol. 2017 Feb;25(1):31-40. doi: 10.1037/pha0000105.
Adolescent brains are particularly susceptible to the rewarding properties of risky decisions in social contexts. Individual differences in genetic influences on dopamine transmission moderate neural outcome processing of risky decisions and may exert pronounced effects on adolescent risk-taking behavior (RTB) and corresponding neural outcome processing in peer contexts, a process called gene-environment interaction (G × E). Eighty-five undergraduate students completed a behavioral risk task alone and in the presence of a confederate peer providing "risky" feedback. We tested for G × E effects using a polygenic risk index that included 3 candidate genetic variations associated with high dopamine transmission efficiency, as well as the moderating role of family history of behavioral disinhibition. Difference waves for the P300 and FRN (i.e., feedback-related negativity) were examined as indices of neural outcome processing. A G × E effect was observed for RTB and the P300, but not the FRN. Family history of behavioral disinhibition also interacted with peer influence to predict P300 amplitude. These data provide preliminary evidence for G × E for peer-influenced RTB and neural outcome processing during late adolescence. Genetic influences on dopaminergic function may be particularly relevant for attentional and motivational neural systems, as indexed by the P300, which exert downstream effects on peer-influenced RTB. (PsycINFO Database Record
青少年的大脑在社交情境中对冒险决策的奖励特性特别敏感。基因对多巴胺传递的影响存在个体差异，这种差异会调节冒险决策的神经结果处理，并可能对青少年的冒险行为（RTB）以及同伴情境中的相应神经结果处理产生显著影响，这一过程称为基因 - 环境相互作用（G×E）。八十五名本科生独自完成了一项行为风险任务，并且在有一名提供“冒险”反馈的同伴在场的情况下再次完成该任务。我们使用一个多基因风险指数来测试G×E效应，该指数包括3个与高多巴胺传递效率相关的候选基因变异，以及行为抑制不足家族史的调节作用。将P300和FRN（即反馈相关负波）的差异波作为神经结果处理的指标进行检查。在RTB和P300方面观察到了G×E效应，但在FRN方面未观察到。行为抑制不足家族史也与同伴影响相互作用，以预测P300波幅。这些数据为青春期后期同伴影响的RTB和神经结果处理中的G×E提供了初步证据。对多巴胺能功能的基因影响可能与注意力和动机神经系统特别相关，如P300所示，它对同伴影响的RTB产生下游效应。（PsycINFO数据库记录
