Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit.
作者信息
Rotman Yaron, Neuschwander-Tetri Brent A
机构信息
Liver & Energy Metabolism Unit Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO.
出版信息
Hepatology. 2017 Apr;65(4):1088-1090. doi: 10.1002/hep.29094. Epub 2017 Mar 3.
Abstract
摘要
相似文献
1
Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit.肝脏脂肪堆积作为胰岛素反应性的一个指标，再次表明脂肪组织是罪魁祸首。
Hepatology. 2017 Apr;65(4):1088-1090. doi: 10.1002/hep.29094. Epub 2017 Mar 3.
2
Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit.肝脏脂肪堆积作为胰岛素反应性的晴雨表，再次表明脂肪组织是罪魁祸首。
Hepatology. 2017 Jul;66(1):296-297. doi: 10.1002/hep.29150. Epub 2017 May 26.
3
Adipose tissue and the insulin resistance syndrome.脂肪组织与胰岛素抵抗综合征。
Proc Nutr Soc. 2001 Aug;60(3):375-80. doi: 10.1079/pns200195.
4
High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice.在C57BL/6j小鼠中，高脂饮食诱导的肥胖在肝脏出现炎症之前，先引发了脂肪组织的炎症。
Aging (Albany NY). 2015 Apr;7(4):256-68. doi: 10.18632/aging.100738.
5
Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults.肥胖和胰岛素抵抗与成年人血清和脂肪组织类胡萝卜素浓度呈负相关。
J Nutr. 2020 Jan 1;150(1):38-46. doi: 10.1093/jn/nxz184.
6
Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity.皮下脂肪组织中巨噬细胞标志物和11β-羟类固醇脱氢酶1（11β-HSD-1）的表达增加，而非培养的单核细胞衍生巨噬细胞中的表达增加，与人类肥胖中的肝脏脂肪有关。
Int J Obes (Lond). 2007 Oct;31(10):1617-25. doi: 10.1038/sj.ijo.0803635. Epub 2007 Apr 24.
7
Tissue-specific activation of insulin signaling as a potential target for obesity-related metabolic disorders.组织特异性胰岛素信号激活作为肥胖相关代谢紊乱的潜在靶点。
Pharmacol Ther. 2024 Oct;262:108699. doi: 10.1016/j.pharmthera.2024.108699. Epub 2024 Aug 5.
8
Divergent pathways of liver fat accumulation, oxidation, and secretion in lipodystrophy versus obesity-associated NAFLD.脂肪营养不良与肥胖相关的非酒精性脂肪性肝病中肝脏脂肪堆积、氧化和分泌的不同途径。
Liver Int. 2023 Dec;43(12):2692-2700. doi: 10.1111/liv.15707. Epub 2023 Aug 25.
9
Body fat distribution and insulin resistance.体脂肪分布与胰岛素抵抗。
Nutrients. 2013 Jun 5;5(6):2019-27. doi: 10.3390/nu5062019.
10
Obesity and metabolic disease: is adipose tissue the culprit?肥胖与代谢性疾病：脂肪组织是罪魁祸首吗？
Proc Nutr Soc. 2005 Feb;64(1):7-13. doi: 10.1079/pns2004403.
引用本文的文献
1
CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease.心脏-肾脏-糖尿病-肝脏-代谢综合征（CARDIAL-MS）：一种综合多系统代谢疾病的新定义。
Diabetol Metab Syndr. 2025 Jun 16;17(1):218. doi: 10.1186/s13098-025-01796-4.
2
Even moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age.即使在传统脂肪肝截断值以下，肝脏脂肪积累也与亚洲育龄妇女的多种代谢组学改变和妊娠期血糖异常有关。
BMC Med. 2024 Nov 27;22(1):561. doi: 10.1186/s12916-024-03779-0.
3
Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens.肉鸡低蛋白日粮中膳食氨基酸谱及氨基酸平衡相关生物标志物的评估
J Anim Sci Biotechnol. 2024 Nov 14;15(1):157. doi: 10.1186/s40104-024-01108-2.
4
LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice.LRP1 通过改善高脂肪饮食喂养小鼠的胰岛素信号通路促进肝糖原生成。
Animal Model Exp Med. 2024 Oct;7(5):696-706. doi: 10.1002/ame2.12408. Epub 2024 Apr 3.
5
Association between Major Adverse Cardiovascular Events and the Liver Fibrosis Score in Patients with and without Coronary Artery Disease: From the FU-CCTA Registry.冠心病患者和非冠心病患者主要不良心血管事件与肝纤维化评分之间的关联：来自FU-CCTA注册研究
J Clin Med. 2023 Sep 15;12(18):5987. doi: 10.3390/jcm12185987.
6
Sweeping 'Metabolic Dysfunction' off the Front Foot - Deceived by the "Wrong 'un": Implications of Dysmetabolism Analysis in Healthy Subjects.摆脱前脚的“代谢功能障碍”——被“错误者”误导：健康受试者中代谢异常分析的影响
J Clin Exp Hepatol. 2023 May-Jun;13(3):547-548. doi: 10.1016/j.jceh.2022.12.010. Epub 2022 Dec 23.
7
Recent evaluation about inflammatory mechanisms in nonalcoholic fatty liver disease.非酒精性脂肪性肝病炎症机制的最新评估
Front Pharmacol. 2023 Mar 16;14:1081334. doi: 10.3389/fphar.2023.1081334. eCollection 2023.
8
Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study.结合脂肪与肌肉比例和丙氨酸氨基转移酶/天冬氨酸氨基转移酶比例预测心脏代谢风险：一项横断面研究
Diabetes Metab Syndr Obes. 2023 Mar 15;16:795-806. doi: 10.2147/DMSO.S401024. eCollection 2023.
9
Cardiac abnormalities in patients with nonalcoholic fatty liver disease.非酒精性脂肪性肝病患者的心脏异常。
Rev Assoc Med Bras (1992). 2022 Nov 21;68(10):1394-1399. doi: 10.1590/1806-9282.20220263. eCollection 2022.
10
Independent Dose-Response Associations between Fetuin-A and Lean Nonalcoholic Fatty Liver Disease.胎球蛋白 A 与瘦型非酒精性脂肪性肝病之间的独立剂量-反应关系。
Nutrients. 2021 Aug 24;13(9):2928. doi: 10.3390/nu13092928.
本文引用的文献
1
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.美国胃肠病学会临床指南：异常肝功能检查结果的评估
Am J Gastroenterol. 2017 Jan;112(1):18-35. doi: 10.1038/ajg.2016.517. Epub 2016 Dec 20.
2
The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance.c-Jun氨基末端激酶（JNKs）在肥胖和胰岛素抵抗中的作用。
J Physiol. 2016 Jan 15;594(2):267-79. doi: 10.1113/JP271457. Epub 2015 Dec 14.
3
Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis.非酒精性脂肪性肝炎患者接受噻唑烷二酮治疗期间，脂肪组织胰岛素抵抗变化对组织学反应的重要性。
Hepatology. 2009 Oct;50(4):1087-93. doi: 10.1002/hep.23116.
4
Influence of local reference populations on upper limits of normal for serum alanine aminotransferase levels.当地参考人群对血清丙氨酸氨基转移酶水平正常上限的影响。
Arch Intern Med. 2008 Mar 24;168(6):663-6. doi: 10.1001/archinternmed.2007.131.
5
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.在肥胖受试者中，肝脏、肌肉和脂肪组织的胰岛素作用与肝内甘油三酯含量直接相关。
Gastroenterology. 2008 May;134(5):1369-75. doi: 10.1053/j.gastro.2008.01.075. Epub 2008 Jan 30.
6
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.非酒精性脂肪性肝病肥胖男性和女性的脂肪组织及肝脏脂质动力学改变
Gastroenterology. 2008 Feb;134(2):424-31. doi: 10.1053/j.gastro.2007.11.038. Epub 2007 Nov 28.
7
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.美国城市人口中肝脂肪变性的患病率：种族的影响。
Hepatology. 2004 Dec;40(6):1387-95. doi: 10.1002/hep.20466.
8
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.磁共振波谱法测量肝脏甘油三酯含量：普通人群中肝脂肪变性的患病率
Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E462-8. doi: 10.1152/ajpendo.00064.2004. Epub 2004 Aug 31.
9
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.在正常男性中，肝脏脂肪堆积与胰岛素抑制葡萄糖生成及血清游离脂肪酸的缺陷有关，且与肥胖无关。
J Clin Endocrinol Metab. 2002 Jul;87(7):3023-8. doi: 10.1210/jcem.87.7.8638.
10
Updated definitions of healthy ranges for serum alanine aminotransferase levels.血清丙氨酸氨基转移酶水平健康范围的更新定义。
Ann Intern Med. 2002 Jul 2;137(1):1-10. doi: 10.7326/0003-4819-137-1-200207020-00006.
Zotero 插件