Zhou Min, Xing Huan-Huan, Yang Yan, Wang Yue-De, Zhou Kun, Dong Wei, Li Gan-Peng, Hu Wei-Yao, Liu Qiang, Li Xue-Mei, Hu Qiu-Fen
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.
b Technology Center, China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
J Asian Nat Prod Res. 2017 Nov;19(11):1073-1078. doi: 10.1080/10286020.2017.1285911. Epub 2017 Feb 2.
Three previously unreported anthraquinones, fistulaquinones A-C (1-3), together with three known ones (4-6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1-6 exhibited moderate cytotoxicity with IC values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.
从决明的嫩枝中分离出三种之前未报道过的蒽醌类化合物，即瘘管醌A - C（1 - 3），以及三种已知的蒽醌类化合物（4 - 6）。通过广泛的核磁共振（NMR）和质谱（MS）光谱分析确定了它们的结构。对所有分离出的化合物进行了抗烟草花叶病毒（anti - TMV）活性测试，化合物3表现出显著活性，在20μM浓度下抑制率为34.5%，甚至比阳性对照更有效。此外，化合物1 - 6对一些测试的人类肿瘤细胞系表现出中等程度的细胞毒性，IC值范围为2.8至9.4μM。
