Tv Vineethkumar, R Asha, G Shyla, George Sanil
Molecular Ecology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.
Chemical Biology Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.
Microb Pathog. 2017 Mar;104:287-288. doi: 10.1016/j.micpath.2017.01.052. Epub 2017 Jan 30.
Antimicrobial peptides (brevinin1 HYba1 and brevinin1 HYba2) identified from the skin secretion of an endemic frog species of Western Ghats were studied against fish pathogens. Post-translational modifications such as c-terminal amidation and cyclization of the peptides were enhanced on the activity against Aeromonas sobria. Based on the Minimum inhibitory concentration (3 μM), cyclic amidated brevinin Hyba2 was identified as the most promising antimicrobial agent against A. sobria and can be developed further as a lead drug molecule.
对从西高止山脉一种特有蛙类皮肤分泌物中鉴定出的抗菌肽（brevinin1 HYba1和brevinin1 HYba2）针对鱼类病原体进行了研究。肽的翻译后修饰，如c端酰胺化和环化，增强了对温和气单胞菌的活性。根据最低抑菌浓度（3μM），环化酰胺化的brevinin Hyba2被确定为针对温和气单胞菌最有前景的抗菌剂，可进一步开发为先导药物分子。
