Zohrab Fatemeh, Askarian Saeedeh, Jalili Amin, Kazemi Oskuee Reza
1Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Int J Pept Res Ther. 2019;25(1):39-48. doi: 10.1007/s10989-018-9723-8. Epub 2018 Jun 5.
The Brevinin peptides are antimicrobial agents obtained from frog skin secretions. Brevinin-2R has attracted many attentions due to its very low hemolytic activity, cationic property, and high affinity to cancer cells. Moreover, it has shown little toxicity against normal mammalian cells, while having killed several tumor cell lines by activation of lysosome-mitochondrial death pathway. In this review, we introduced the Brevinin superfamily with a focus on its therapeutic applications. Next, some unique properties of Brevinins were briefly discussed, including their ability to stimulate insulin secretion, dendritic cell maturation, and wound healing. In this context, we also provide information about the decoration of nanoparticles, such as cerium nano-oxide, by Brevinins. Finally, we addressed their potential for anti-tumor and drug design applications.
Brevinin肽是从青蛙皮肤分泌物中获得的抗菌剂。Brevinin-2R因其极低的溶血活性、阳离子特性以及对癌细胞的高亲和力而备受关注。此外，它对正常哺乳动物细胞几乎没有毒性，同时通过激活溶酶体-线粒体死亡途径杀死了几种肿瘤细胞系。在这篇综述中，我们介绍了Brevinin超家族，并重点关注其治疗应用。接下来，简要讨论了Brevinin的一些独特特性，包括它们刺激胰岛素分泌、树突状细胞成熟和伤口愈合的能力。在此背景下，我们还提供了有关用Brevinin修饰纳米颗粒（如氧化铈纳米颗粒）的信息。最后，我们探讨了它们在抗肿瘤和药物设计应用方面的潜力。
