Ryder Justin R, Pankratz Nathan D, Dengel Donald R, Pankow James S, Jacobs David R, Sinaiko Alan R, Gooty Vasu, Steinberger Julia
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN
Department of Lab Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN.
J Am Heart Assoc. 2017 Feb 2;6(2):e004757. doi: 10.1161/JAHA.116.004757.
Understanding the heritable contribution of vascular measures, from parent to offspring, may aid in risk stratification and atherosclerosis prevention efforts. We hypothesized that measures of vascular structure and function would be heritable in this cohort of parents and their adolescent offspring.
High-resolution ultrasound scans of the brachial and carotid arteries were obtained in parents (n=558) and their offspring (n=369). Lumen diameter and flow-mediated dilation were measured in the brachial artery. Intima-media thickness, lumen diameter, incremental elastic modulus, diameter distensibility, and cross-sectional distensibility were measured, and carotid cross-sectional compliance was measured in the carotid artery. Carotid-radial pulse wave velocity was obtained using SphygmoCor. Heritability analysis (h, expressed as %) using Sequential Oligogenic Linkage Analysis Routines was performed on the entire cohort and adjusted for age, sex, race, body-mass index, smoking, and mean arterial pressure. Data are presented as mean±SE. Measures of brachial artery diameter (h=25±9%, P=0.001), lumen diameter (h=55±9%, P<0.001), intima-media thickness (h=29±13%, P=0.014), diameter distensibility (h=28±7%, P<0.001), cross-sectional distensibility (h=27±7%, P<0.001), and pulse wave velocity (h=26±9%, P<0.001) were significantly heritable. Flow-mediated dilation and incremental elastic modulus were not significantly heritable. Similar associations were observed in analysis restricted to siblings and complete Trios (mother, father, and child).
These data show that the majority of noninvasive measures of vascular structure and function are heritable, suggesting that measurement of these subclinical risk factors in parents may be helpful in assessing childhood risk for future cardiovascular disease.
了解血管测量指标从父母到后代的遗传贡献，可能有助于进行风险分层和预防动脉粥样硬化。我们假设血管结构和功能的测量指标在这组父母及其青春期后代中具有遗传性。
对558名父母及其369名后代进行了肱动脉和颈动脉的高分辨率超声扫描。测量肱动脉的管腔直径和血流介导的血管舒张功能。测量颈动脉的内膜中层厚度、管腔直径、增量弹性模量、直径扩张性、横截面积扩张性，并测量颈动脉横截面积顺应性。使用SphygmoCor获得颈-桡脉搏波速度。使用序列寡基因连锁分析程序对整个队列进行遗传力分析（h，以%表示），并对年龄、性别、种族、体重指数、吸烟和平均动脉压进行校正。数据以平均值±标准误表示。肱动脉直径（h=25±9%，P=0.001）、管腔直径（h=55±9%，P<0.001）、内膜中层厚度（h=29±13%，P=0.014）、直径扩张性（h=28±7%，P<0.001）、横截面积扩张性（h=27±7%，P<0.001）和脉搏波速度（h=26±9%，P<0.001）的测量指标具有显著遗传性。血流介导的血管舒张功能和增量弹性模量没有显著遗传性。在仅限于兄弟姐妹和完整三人组（母亲、父亲和孩子）的分析中也观察到了类似的关联。
这些数据表明，大多数血管结构和功能的非侵入性测量指标具有遗传性，这表明测量父母的这些亚临床风险因素可能有助于评估儿童未来患心血管疾病的风险。
