原生动物寄生虫与I型干扰素
Protozoan Parasites and Type I IFNs.
作者信息
Silva-Barrios Sasha, Stäger Simona
机构信息
INRS-Institut Armand Frappier, Center for Host-Parasite Interactions , Laval, QC , Canada.
出版信息
Front Immunol. 2017 Jan 19;8:14. doi: 10.3389/fimmu.2017.00014. eCollection 2017.
Abstract
For many years, the role of interferon (IFN)-I has been characterized primarily in the context of viral infections. However, regulatory functions mediated by IFN-I have also been described against bacterial infections and in tumor immunology. Only recently, the interest in understanding the immune functions mediated by IFN-I has dramatically increased in the field of protozoan infections. In this review, we discuss the discrete role of IFN-I in the immune response against major protozoan infections: , and .
摘要
多年来，I型干扰素（IFN）的作用主要是在病毒感染的背景下得以描述。然而，I型干扰素介导的调节功能在对抗细菌感染及肿瘤免疫学方面也有相关报道。直到最近，在原生动物感染领域，人们对了解I型干扰素介导的免疫功能的兴趣急剧增加。在这篇综述中，我们讨论了I型干扰素在针对主要原生动物感染（即 、 和 ）的免疫反应中的不同作用。
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