von Kleist S, King M, Havemann K
J Natl Cancer Inst. 1978 Dec;61(6):1385-91.
Nonspecific cross-reacting antigen (NCA), which strongly cross-reacts with carcinoembryonic antigen, was demonstrated to be an autoantigen. Antibodies directed against NCA were shown in different groups of patients, but high titers (greater than 1/64) were found only in cancer patients. A correlation between tumor mass, antigen load, and antibody titer apparently existed. Sera obtained from patients preoperatively and postoperatively differed significantly (P greater than 0.01) in the sense that titers were high only in sera sampled after the patients were treated. Nevertheless, the formation of these antibodies cannot be considered a cancer-specific phenomenon because of their existence also in patients with nonmalignant diseases.
非特异性交叉反应抗原（NCA）与癌胚抗原有强烈的交叉反应，已被证明是一种自身抗原。在不同组的患者中均检测到了针对NCA的抗体，但仅在癌症患者中发现了高滴度（大于1/64）的抗体。肿瘤大小、抗原负荷和抗体滴度之间显然存在相关性。术前和术后采集的患者血清存在显著差异（P大于0.01），即仅在患者接受治疗后采集的血清中滴度较高。然而，这些抗体的形成不能被视为癌症特异性现象，因为在非恶性疾病患者中也存在此类抗体。
