循环癌胚抗原免疫复合物是否为胃肠道癌患者的预后标志物？
Are circulating CEA immune complexes a prognostic marker in patients with carcinoma of the gastrointestinal tract?
作者信息
Staab H J, Anderer F A, Stumpf E, Fischer R
出版信息
Br J Cancer. 1980 Jul;42(1):26-33. doi: 10.1038/bjc.1980.199.
Abstract
CEA immune complexes and free CEA were determined to 363 patients with histologically confirmed adenocarcinoma of the gastrointestinal tract before surgery and in a post-operative follow-up. Circulating CEA immune complexes (CEA-IC) could be detected preoperatively in 89 patients. Incidence of CEA-IC increased with increasing tumour extension; 72/89 patients with CEA-IC showed already metastatic disease progression, 40/89 had nonresectable tumours. Patients with preoperative CEA-IC had a poorer prognosis than patients without CEA-IC but with high levels of free CEA, or CEA-negative patients. The appearance of CEA-IC with consecutive increases in the postoperative follow-up indicated disease recurrence. In 32/55 relapse cases, circulating CEA-IC were detected postoperatively, all 32 cases developing metastatic spread of disease.
摘要
对363例经组织学确诊的胃肠道腺癌患者在手术前及术后随访期间测定了癌胚抗原（CEA）免疫复合物和游离CEA。术前可在89例患者中检测到循环CEA免疫复合物（CEA-IC）。CEA-IC的发生率随肿瘤扩展程度的增加而升高；89例CEA-IC患者中72例已出现转移性疾病进展，40例为不可切除肿瘤。术前有CEA-IC的患者比没有CEA-IC但游离CEA水平高的患者或CEA阴性患者预后更差。术后随访中CEA-IC持续升高提示疾病复发。在55例复发病例中的32例，术后检测到循环CEA-IC，所有32例均发生了疾病的转移性扩散。
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Are circulating CEA immune complexes a prognostic marker in patients with carcinoma of the gastrointestinal tract?循环癌胚抗原免疫复合物是否为胃肠道癌患者的预后标志物？
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本文引用的文献
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Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies.胃肠道恶性肿瘤患者体内缺乏癌胚抗原循环抗体。
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Further investigations of circulating antibodies in colon cancer patients: on the autoantigenicity of the carcinoembryonic antigen.结肠癌患者循环抗体的进一步研究：关于癌胚抗原的自身抗原性
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Brief communication: carcinoembryonic antigen in colon cancer: absence in perchloric acid precipitates of plasma.简短通讯：结肠癌中的癌胚抗原：血浆高氯酸沉淀中不存在
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Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumour-specific antigen-antibody complexes.肿瘤特异性抗原-抗体复合物对大鼠肝癌细胞淋巴细胞介导细胞毒性的阻断作用。
Nat New Biol. 1972 Aug 9;238(84):185-6. doi: 10.1038/newbio238185a0.
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Circulating immune complexes in human neuroblastoma: direct assay and role in blocking specific cellular immunity.人类神经母细胞瘤中的循环免疫复合物：直接检测及其在阻断特异性细胞免疫中的作用
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Neoantigens on spontaneous and carcinogen-induced rat tumors defined by in vitro lymphocytotoxicity assays.通过体外淋巴细胞毒性试验确定的自发性和致癌物诱导的大鼠肿瘤上的新抗原
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