循环癌胚抗原免疫复合物是否为胃肠道癌患者的预后标志物？
Are circulating CEA immune complexes a prognostic marker in patients with carcinoma of the gastrointestinal tract?
作者信息
Staab H J, Anderer F A, Stumpf E, Fischer R
出版信息
Br J Cancer. 1980 Jul;42(1):26-33. doi: 10.1038/bjc.1980.199.
Abstract
CEA immune complexes and free CEA were determined to 363 patients with histologically confirmed adenocarcinoma of the gastrointestinal tract before surgery and in a post-operative follow-up. Circulating CEA immune complexes (CEA-IC) could be detected preoperatively in 89 patients. Incidence of CEA-IC increased with increasing tumour extension; 72/89 patients with CEA-IC showed already metastatic disease progression, 40/89 had nonresectable tumours. Patients with preoperative CEA-IC had a poorer prognosis than patients without CEA-IC but with high levels of free CEA, or CEA-negative patients. The appearance of CEA-IC with consecutive increases in the postoperative follow-up indicated disease recurrence. In 32/55 relapse cases, circulating CEA-IC were detected postoperatively, all 32 cases developing metastatic spread of disease.
摘要
对363例经组织学确诊的胃肠道腺癌患者在手术前及术后随访期间测定了癌胚抗原（CEA）免疫复合物和游离CEA。术前可在89例患者中检测到循环CEA免疫复合物（CEA-IC）。CEA-IC的发生率随肿瘤扩展程度的增加而升高；89例CEA-IC患者中72例已出现转移性疾病进展，40例为不可切除肿瘤。术前有CEA-IC的患者比没有CEA-IC但游离CEA水平高的患者或CEA阴性患者预后更差。术后随访中CEA-IC持续升高提示疾病复发。在55例复发病例中的32例，术后检测到循环CEA-IC，所有32例均发生了疾病的转移性扩散。
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