School of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou, 221116, China.
J Org Chem. 2017 Mar 3;82(5):2462-2471. doi: 10.1021/acs.joc.6b02850. Epub 2017 Feb 13.
A substrate-controlled regioselective arylation of 2-indolylmethanols with indoles has been established, which efficiently afforded bis(indolyl)methane and 3,3'-bisindole derivatives in high yields and with a broad substrate scope (up to 98% yield, 36 examples). This approach will not only provide an important strategy for the diversified synthesis of bis(indolyl)methane and 3,3'-bisindole derivatives but also serve as a good example for substrate-controlled regioselective reactions.
建立了一种 2-吲哚甲醇与吲哚的底物控制的区域选择性芳基化反应，该反应以高产率和广泛的底物范围（高达 98%的产率，36 个实例）有效地得到了双（吲哚基）甲烷和 3,3'-双吲哚衍生物。这种方法不仅为双（吲哚基）甲烷和 3,3'-双吲哚衍生物的多样化合成提供了重要策略，而且为底物控制的区域选择性反应树立了良好的范例。
