Xiong Yan, Wang Xuhong, Jiang Wentao, Tian Xiaobao, Wang Qingyuan, Fan Yubo, Chen Yu
School of Manufacturing Science and Engineering, Sichuan University, 610065, Chengdu, China.
Department of Applied Mechanics, Sichuan University, 610065, Chengdu, China.
Biomed Eng Online. 2016 Dec 28;15(Suppl 2):134. doi: 10.1186/s12938-016-0248-0.
The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac.
Comparisons of 3D numerical models with/without a MS in an abdominal aortic aneurysm with a 90° branch vessel were numerically studied from the viewpoint of hemodynamics.
The results showed that: (1) The flow fields and Wall Shear Stress (WSS) are changed dramatically after MS implantation. The velocity of the blood flow in aneurysm sac decreases significantly and the regions of low-WSS increase. These help thrombus formation; (2) The pressure in aneurysm slightly decreases and keeps close to the normal level of blood pressure, however the risk of aneurysm enlargement or even rupture still exists; (3) The flux and the velocity in branch artery are reduced by about half after MS implantation. Due to the implantation of MS, the changes in the flow field causes the decrease of pressure/WSS in aneurysm sac and the blood flow in branch vessel.
The implantation of MS into abdominal artery results in more low-WSS regions inside aneurysm which induces thrombus formation. The pressure is reduced slightly means the risk of aneurysm rupture exists.
多层支架(MS)植入引起的血流动力学变化对动脉瘤囊有显著影响。
从血流动力学角度对有/无MS的90°分支血管腹主动脉瘤的三维数值模型进行了数值研究。
结果表明:(1)MS植入后流场和壁面切应力(WSS)发生显著变化。动脉瘤囊内血流速度显著降低,低WSS区域增加。这些有助于血栓形成;(2)动脉瘤内压力略有降低并接近正常血压水平,但动脉瘤扩大甚至破裂的风险仍然存在;(3)MS植入后分支动脉中的通量和速度降低约一半。由于MS的植入,流场的变化导致动脉瘤囊内压力/WSS和分支血管内血流的降低。
在腹主动脉植入MS会导致动脉瘤内出现更多低WSS区域,从而诱导血栓形成。压力略有降低意味着存在动脉瘤破裂的风险。