具有各种碳环骨架的倍半萜类化合物来自于野菊花的花朵。
Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum.
机构信息
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) , Lanzhou 730000, People's Republic of China.
Korea Bioactive Natural Material Bank, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul 08826, Republic of Korea.
出版信息
J Nat Prod. 2017 Feb 24;80(2):298-307. doi: 10.1021/acs.jnatprod.6b00694. Epub 2017 Feb 3.
A phytochemical investigation of the flowers of Chrysanthemum indicum yielded sesquiterpenoids 1-25 with various carbocyclic skeletons, including 10 new (1-10) and 15 known (11-25) analogues. The structures were elucidated via their physical data, while the absolute configuration of compounds 6, 8, and 10 was assessed via electronic circular dichroism analysis. The evaluation of the effect of sesquiterpenoids on porcine epidemic diarrhea virus (PEDV) replication showed that compounds 1-5, 12, 14, 16, 17, 19, and 21 increased cell viability against cell death in PEDV-injected cells. Compounds 2, 12, and 17 were selected and investigated for their inhibition of proteins required for PEDV replication. Compounds 2 and 17 significantly reduced PEDV nucleocapsid and spike protein synthesis compared with azauridin as a positive control.
对菊花花的植物化学研究得到了具有各种碳环骨架的倍半萜类化合物 1-25，包括 10 个新的（1-10）和 15 个已知的（11-25）类似物。结构通过其物理数据阐明，而化合物 6、8 和 10 的绝对构型则通过电子圆二色性分析进行评估。评估倍半萜类化合物对猪流行性腹泻病毒（PEDV）复制的影响表明，化合物 1-5、12、14、16、17、19 和 21 增加了细胞活力，对抗 PEDV 感染细胞的细胞死亡。选择化合物 2、12 和 17 并研究它们对 PEDV 复制所需蛋白质的抑制作用。与作为阳性对照的氮杂尿嘧啶相比，化合物 2 和 17 显著降低了 PEDV 核衣壳和刺突蛋白的合成。
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