TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Division of Biological Sciences, University of California San Diego, San Diego, CA 95101, USA.
Molecules. 2021 May 19;26(10):3038. doi: 10.3390/molecules26103038.
Plants from the genus are rich sources of chemical diversity and, in recent years, have been the focus of research on natural products chemistry. Sesquiterpenoids are one of the major classes of chemical constituents reported from this genus. To date, more than 135 sesquiterpenoids have been isolated and identified from the whole genus. These include 26 germacrane-type, 26 eudesmane-type, 64 guaianolide-type, 4 bisabolane-type, and 15 other-type sesquiterpenoids. Pharmacological studies have proven the biological potential of sesquiterpenoids isolated from species, reporting anti-inflammatory, antibacterial, antitumor, insecticidal, and antiviral activities for these interesting molecules. In this paper, we provide information on the chemistry and bioactivity of sesquiterpenoids obtained from the genus which could be used as the scientific basis for their future development and utilization.
该属植物是化学多样性的丰富来源，近年来一直是天然产物化学研究的重点。倍半萜类化合物是该属报道的主要化学成分之一。迄今为止，已经从整个属中分离和鉴定出超过 135 种倍半萜类化合物。其中包括 26 种倍半萜型、26 种愈创木烷型、64 种愈创木烷型、4 种倍半萜型和 15 种其他类型的倍半萜类化合物。药理研究证明了从该属植物中分离得到的倍半萜类化合物的生物潜力，这些有趣的分子具有抗炎、抗菌、抗肿瘤、杀虫和抗病毒活性。本文提供了从该属植物中获得的倍半萜类化合物的化学和生物活性信息，可为其未来的开发利用提供科学依据。
