Nuzhnyĭ V P, Tezikov E B, Zabirova I G, Ugriumov A I
Vopr Med Khim. 1989 Jul-Aug;35(4):16-20.
Increase in content of II-oxycorticosteroids and in activity of dopamine-beta-hydroxylase in blood serum, decrease in concentration of adrenaline in adrenal glands with simultaneous accumulation of the catecholamine in myocardium were observed in rats after intensive alcoholization within 5 days (intragastric administration of ethanol 4-5 g/kg twice daily). In this case content of noradrenaline and its density in the catecholamine-containing nervous fibers were decreased. Ethanol abolishing, as shown by dynamics of catecholamines in heart and adrenal glands, caused an additive stimulation of the sympathoadrenal system, which reached the maximal level within a day and accomplished within 3 days after the last ethanol injection. Abolishing of ethanol led to an increase in the rate of creatine kinase elimination from isolated perfused heart and to activation of the enzyme in rat blood, which reached the maximal value within 3-7 days after the last injection of ethanol. Development of myocardium impairments correlated with accumulation of catecholamines in extraneuronal structures of heart tissue.
在大鼠连续5天大量饮酒（每天两次胃内给予4 - 5 g/kg乙醇）后，观察到血清中II - 氧皮质类固醇含量增加、多巴胺 - β - 羟化酶活性增强，肾上腺中肾上腺素浓度降低，同时心肌中儿茶酚胺蓄积。在此情况下，去甲肾上腺素含量及其在含儿茶酚胺神经纤维中的密度降低。从心脏和肾上腺中儿茶酚胺的动态变化可知，乙醇消除后会对交感 - 肾上腺系统产生累加刺激，在末次注射乙醇后1天内达到最大水平，并在3天内完成。停止给予乙醇会导致离体灌注心脏中肌酸激酶清除率增加以及大鼠血液中该酶的活性激活，在末次注射乙醇后3 - 7天达到最大值。心肌损伤的发展与儿茶酚胺在心脏组织神经外结构中的蓄积相关。
