[Catecholamine concentration in blood, heart, and adrenals of rats following intraperitoneal injections of a cardiotoxic dose of adrenaline against a background of arfonad and rausedyl administration].

A study was made of the adrenaline and noradrenaline content in the blood, myocardium and adrenals of 74 male Wistar rats. Four series of experiments were conducted with administration of noradrenaline alone and noradrenaline after premedication with arfonad (ganglion-blocking agent) or rausedil (reserpine drug). Distilled water was used in control experiments. The content of adrenaline and noradrenaline in blood and tissues was shown to change 45 seconds after noradrenaline administration and to return to normal by the 7th minute. Correlation of the catecholamine content in rat blood and tissues with morphological changes in the myocardium recorded in the analogous series of experiments has shown that the increased content of catecholamines in bloods is one of the most important factors in the pathogenesis of myocardial injury since the diminution of their content during ganglionic blockade is associated with a reduced heart injury. The noradrenaline content in the myocardium does not correlate with the severity of myocardial injury.