Adams M A, Hirst M
Subst Alcohol Actions Misuse. 1982;3(5):287-98.
It has been found that a short period of severe intoxication with ethanol produces a marked reduction of adrenal catecholamines. Animals so treated demonstrate moderate to severe withdrawal signs. Accordingly, adrenal and urinary catecholamines were determined in rats undergoing withdrawal after treatment with several drugs known to modify sympathetic function. The depressant diazepam obtained withdrawal severity without altering peripheral catecholamines, propranolol reduced urinary catecholamines and transiently ameliorated withdrawal, whereas hexamethonium elevated urinary catecholamines and enhanced the severity of withdrawal. No drug treatment modified adrenal catecholamine levels. In this model the attenuation of adrenergic function has no consistent influence on the manifestation of withdrawal after ethanol.
已经发现，短时间严重乙醇中毒会使肾上腺儿茶酚胺显著减少。经如此处理的动物表现出中度至重度的戒断症状。因此，在用几种已知可改变交感神经功能的药物治疗后处于戒断状态的大鼠中，测定了肾上腺和尿中的儿茶酚胺。镇静剂地西泮在不改变外周儿茶酚胺的情况下减轻了戒断严重程度，普萘洛尔降低了尿儿茶酚胺并短暂改善了戒断症状，而六甲铵则升高了尿儿茶酚胺并加重了戒断严重程度。没有药物治疗改变肾上腺儿茶酚胺水平。在这个模型中，肾上腺素能功能的减弱对乙醇戒断后的表现没有一致的影响。
