Agadzhanov M I, Simonian M A, Kazarian Sh A
Vopr Med Khim. 1989 Jul-Aug;35(4):28-30.
Content and activity of endogenous superoxide dismutase (SOD) were decreased simultaneously with an increase in the rate of lipid peroxidation under conditions of burns trauma. At the same time, parameters of the EPR signal were unaltered. Administration of exogenous SOD normalized the patterns studied and increased distinctly the survival rate of rats.
在烧伤创伤条件下,内源性超氧化物歧化酶(SOD)的含量和活性随脂质过氧化速率的增加而同时降低。与此同时,电子顺磁共振(EPR)信号参数未发生改变。给予外源性SOD可使所研究的各项指标恢复正常,并显著提高大鼠的存活率。