[通过在一天中的不同时间给药来预防细胞抑制剂的副作用]
[The prevention of the side effects of cytostatics by administering them at various times of day].
作者信息
Efimov M L, Vasil'eva G S, Kovalenko V R, Panina T G, Mustafina R Kh
出版信息
Vopr Onkol. 1989;35(9):1068-71.
PMID:2815696
Abstract
Rats bearing Pliss' lymphosarcoma revealed diurnal variations of body temperature. Cyclophosphamide and methotrexate were significantly less toxic when injected at peak temperatures than at minimal ones.
摘要
患有普利斯氏淋巴肉瘤的大鼠呈现出体温的昼夜变化。当在体温峰值时注射环磷酰胺和甲氨蝶呤，其毒性显著低于在体温最低值时注射。
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