Iakovleva T K
Vopr Onkol. 1986;32(7):67-71.
The paper deals with a comparative evaluation of cytogenetic action of cyclophosphamide on tumor and bone marrow cells in intact and radiation--exposed Pliss' lymphosarcoma-bearing mice. In both study groups, the level of cells with drug--induced chromosome damage was shown to be higher in tumor. No significant difference was established between the 2 groups in the effect of cyclophosphamide on similar tissues.
本文对环磷酰胺对完整的和经辐射的携带普利斯氏淋巴肉瘤小鼠的肿瘤细胞和骨髓细胞的细胞遗传学作用进行了比较评估。在两个研究组中，药物诱导染色体损伤的细胞水平在肿瘤中更高。环磷酰胺对相似组织的作用在两组之间未发现显著差异。
