Shang Shanshan, Chen Zhongjiang, Zhao Yue, Yang Sihua, Xing Da
Opt Express. 2017 Jan 23;25(2):530-539. doi: 10.1364/OE.25.000530.
The composition of plaque is a major determinant of coronary-related clinical syndromes. By combining photoacoustic tomography (PAT) and optical coherence tomography (OCT), the optical absorption and scattering properties of vascular plaque can be revealed and subsequently used to distinguish the plaque composition and structure. The feasibility and capacity of the dual-mode PAT-OCT technique for resolving vascular plaque was first testified by plaque composition mimicking experiment. PAT obtained lipid information due to optical absorption differences, while owing to scattering differences, OCT achieved imaging of collagen. Furthermore, by combining PAT and OCT, the morphological characteristic and scattering difference of normal and lipid-rich plaque in the ex vivo rabbit aorta was distinguished simultaneously. The experiments demonstrated that the combined PAT and OCT technique is a potential feasible method for detecting the composition and structure of lipid core and fibrous cap in atherosclerosis.
斑块的组成是冠状动脉相关临床综合征的主要决定因素。通过结合光声断层扫描（PAT）和光学相干断层扫描（OCT），可以揭示血管斑块的光吸收和散射特性，并随后用于区分斑块的组成和结构。双模PAT-OCT技术用于解析血管斑块的可行性和能力首先通过斑块组成模拟实验得到证实。PAT由于光吸收差异获得脂质信息，而OCT则由于散射差异实现胶原蛋白成像。此外，通过结合PAT和OCT，同时区分了离体兔主动脉中正常斑块和富含脂质斑块的形态特征和散射差异。实验表明，联合PAT和OCT技术是检测动脉粥样硬化中脂质核心和纤维帽的组成和结构的一种潜在可行方法。
