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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Deisinger P J, Guest D

Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY 14652-3615.

Xenobiotica. 1989 Sep;19(9):981-9. doi: 10.3109/00498258909043155.

The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. 2. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. 3. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level. 4. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats.

研究了二甘醇丁醚醋酸酯（DGBA）在大鼠血液中的体外水解及其在雄性Sprague-Dawley大鼠体内的代谢和处置情况。2. DGBA（5 mM）在大鼠血液中水解为二甘醇单丁醚（DGBE），半衰期小于3分钟。3. 口服给予200或2000 mg/kg的14C-DGBA后，其迅速从胃肠道吸收，并在24小时内主要通过大鼠尿液排出。主要的尿液代谢产物是2-(2-丁氧基乙氧基)乙酸。在任一剂量水平下，大鼠尿液中均未检测到未变化的DGBA或DGBE。4. 未发现有2-丁氧基乙酸排泄的证据，该物质已被证明对大鼠有血液学影响。

Deisinger P J, Guest D

Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY 14652-3615.

Xenobiotica. 1989 Sep;19(9):981-9. doi: 10.3109/00498258909043155.

The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. 2. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. 3. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level. 4. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats.

研究了二甘醇丁醚醋酸酯（DGBA）在大鼠血液中的体外水解及其在雄性Sprague-Dawley大鼠体内的代谢和处置情况。2. DGBA（5 mM）在大鼠血液中水解为二甘醇单丁醚（DGBE），半衰期小于3分钟。3. 口服给予200或2000 mg/kg的14C-DGBA后，其迅速从胃肠道吸收，并在24小时内主要通过大鼠尿液排出。主要的尿液代谢产物是2-(2-丁氧基乙氧基)乙酸。在任一剂量水平下，大鼠尿液中均未检测到未变化的DGBA或DGBE。4. 未发现有2-丁氧基乙酸排泄的证据，该物质已被证明对大鼠有血液学影响。