Jinks M J, Baker D E
Welsh School of Pharmacy, University of Wales Cardiff College, U.K.
DICP. 1989 Oct;23(10):800-5.
Visitors to developing areas of the world are at high risk for contracting travelers' diarrhea (TD). Despite proven effectiveness in the prevention of TD, prophylactic use of anti-diarrheal agents is controversial. Most authorities recommend against the routine use of drugs for the prevention of TD. This article presents data from surveys of pharmacists and their spouses participating in vacation-study tours to countries associated with a high risk of TD. Patterns of antidiarrheal drug use are compared with the recommended practices regarding both prophylactic and symptomatic therapy. Generally, the subjects in this study adhered closely to recommended practices. Nevertheless, although a majority employed dietary restrictions for TD prevention, 22.8 percent took antidiarrheal drugs prophylactically. Nearly half took antidiarrheal agents for symptomatic use. The ingredients most frequently mentioned matched current recommendations. Inappropriate practices included the use of prophylactic agents without dietary restrictions, and the use of antimotility agents prophylactically. Patterns of dietary and antidiarrheal drug use are compared, including intended versus actual, prophylactic versus symptomatic, and prescription versus nonprescription product use. The controversy regarding the use of prophylactic drug therapy for TD is discussed.
前往世界发展中地区的旅行者感染旅行者腹泻（TD）的风险很高。尽管预防TD已被证明有效，但预防性使用止泻药仍存在争议。大多数权威机构不建议常规使用药物预防TD。本文展示了对参与前往TD高风险国家的度假学习旅行的药剂师及其配偶的调查数据。将止泻药的使用模式与关于预防和对症治疗的推荐做法进行了比较。总体而言，本研究中的受试者严格遵循推荐做法。然而，尽管大多数人采用饮食限制来预防TD，但22.8%的人预防性服用了止泻药。近一半的人服用止泻药用于对症治疗。最常提及的成分与当前推荐相符。不当做法包括在没有饮食限制的情况下使用预防药物，以及预防性使用抗动力药物。比较了饮食和止泻药的使用模式，包括预期与实际、预防与对症以及处方药与非处方药的使用。讨论了关于TD预防性药物治疗使用的争议。
