Department of Health Sciences, University of Leicester, 22-28 Princess Road W, Leicester LE1 6TP, UK.
Diabetes Research Centre, College of Medicine, Biological Sciences & Psychology, University of Leicester, Leicester Diabetes Centre, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK.
J Public Health (Oxf). 2016 Dec 2;38(4):e455-e463. doi: 10.1093/pubmed/fdv162.
In England, coronary heart disease (CHD) mortality has declined, but variations remain.
This study aimed to describe under 75-year CHD mortality variations across geographically defined populations. Regression slopes for mortality data as a function of time were calculated for all 151 English primary care trusts (PCTs), giving the change in the expected age adjusted rate for each extra year.
Between 1993 and 2010, the mean age-standardized CHD mortality rate decreased from 107.76 to 35.12 per 100 000, but the coefficient of variation increased from 0.21 to 0.27. The slope of decline was significantly less after 2004 ( −4.91 for 1993–2003, −3.04 for 2004–2010). The proportion of smokers decreased by 24.6%. The estimated proportion of the population with controlled hypertension increased by 74.4% (2003–2010), but diabetes increased by 138% (1994–2010) and the proportion of obese people increased by 74.3% (1993–2010). There was a greater decline in CHD mortality in PCTs with greater deprivation and smoking (2006–2010).
Since 2004, there has not been a relative reduction of variations in CHD mortality. Appropriate strategies to improve early detection and effective management of risk factors are needed to lower overall CHD mortality further and to reduce persistent variations across England.
在英国,冠心病(CHD)死亡率有所下降,但仍存在差异。
本研究旨在描述按地理位置定义的人群中 75 岁以下 CHD 死亡率的变化。对所有 151 个英国初级保健信托(PCT)的死亡率数据进行回归斜率分析,作为时间的函数,计算每个额外年份预期年龄调整率的变化。
1993 年至 2010 年间,年龄标准化 CHD 死亡率平均值从每 10 万人 107.76 降至 35.12,但变异系数从 0.21 增至 0.27。2004 年后下降斜率明显放缓(1993-2003 年为-4.91,2004-2010 年为-3.04)。吸烟者比例下降了 24.6%。估计高血压得到控制的人群比例增加了 74.4%(2003-2010 年),但糖尿病增加了 138%(1994-2010 年),肥胖人群比例增加了 74.3%(1993-2010 年)。在较贫困和吸烟人群较多的 PCT 中,CHD 死亡率下降幅度更大(2006-2010 年)。
自 2004 年以来,CHD 死亡率的变化并没有相对减少。需要采取适当的策略,改善危险因素的早期发现和有效管理,以进一步降低总体 CHD 死亡率,并减少英格兰各地持续存在的差异。