Liu Yang, Li Jiapeng, Wang Tiansheng, Wang Yitong, Zhao Libo, Fang Yi
Department of Pharmacy, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Maturitas. 2017 Mar;97:44-52. doi: 10.1016/j.maturitas.2016.12.004. Epub 2016 Dec 28.
Preclinical studies have revealed the beneficial effects of genistein in pancreatic β-cell functions. The results of randomized controlled trials (RCTs) in assessing the effects of genistein on glucose metabolism are inconsistent, however. The aim of this meta-analysis is to evaluate the effects of genistein on glucose control and insulin sensitivity in postmenopausal women. This study searched the Medline, PubMed, and Cochrane databases, and ClinicalTrials.gov for trials from January 1970 to February 2016. We included RCTs that investigated the effects of genistein on glucose control and insulin metabolism in postmenopausal women. We also performed pooled analyses with weighted mean difference (WMD) and 95% confidence intervals (CI) according to the RevMan 5.3 software with the random-effects model. Seven eligible RCTs with 670 participants were included in the meta-analysis. Compared with placebos, genistein exhibited significant effects in lowering fasting glucose levels (WMD, -6.35mg/dL [95% CI, -10.78 to -1.93]; P=0.005), fasting insulin concentrations (WMD, -1.92μIU/mL [95% CI, -3.04 to -0.79]; P=0.0008), and HOMA-IR values (WMD, -0.74 [95% CI, -1.21 to -0.28]; P=0.002). Genistein significantly improves glucose control and insulin sensitivity in postmenopausal women. Long-term treatment may have greater effects than short-term use. The role and safety of genistein in glucose control in postmenopausal women require further investigation.
临床前研究已经揭示了染料木黄酮对胰腺β细胞功能的有益作用。然而，评估染料木黄酮对葡萄糖代谢影响的随机对照试验（RCT）结果并不一致。本荟萃分析的目的是评估染料木黄酮对绝经后女性血糖控制和胰岛素敏感性的影响。本研究检索了1970年1月至2016年2月期间的Medline、PubMed、Cochrane数据库以及ClinicalTrials.gov上的试验。我们纳入了研究染料木黄酮对绝经后女性血糖控制和胰岛素代谢影响的随机对照试验。我们还根据RevMan 5.3软件采用随机效应模型进行了加权平均差（WMD）和95%置信区间（CI）的汇总分析。荟萃分析纳入了7项符合条件的随机对照试验，共670名参与者。与安慰剂相比，染料木黄酮在降低空腹血糖水平（WMD，-6.35mg/dL [95% CI，-10.78至-1.93]；P = 0.005）、空腹胰岛素浓度（WMD，-1.92μIU/mL [95% CI，-3.04至-0.79]；P = 0.0008）和HOMA-IR值（WMD，-0.74 [95% CI，-1.21至-0.28]；P = 0.002）方面显示出显著效果。染料木黄酮可显著改善绝经后女性的血糖控制和胰岛素敏感性。长期治疗可能比短期使用有更大的效果。染料木黄酮在绝经后女性血糖控制中的作用和安全性需要进一步研究。
