Department of Food Bioscience & Biotechnology, College of Bioresource Science, Nihon University (UNBS), Fujisawa 282-8510, Japan.
Institute for World Health Development, Mukogawa Women's University, Nishinomiya 663-8143, Japan.
Molecules. 2021 Sep 27;26(19):5863. doi: 10.3390/molecules26195863.
Isoflavones are polyphenols primarily contained in soybean. As phytoestrogens, isoflavones exert beneficial effects on various chronic diseases. Metabolic syndrome increases the risk of death due to arteriosclerosis in individuals with various pathological conditions, including obesity, hypertension, hyperglycemia, and dyslipidemia. Although the health benefits of soybean-derived isoflavones are widely known, their beneficial effects on the pathogenesis of metabolic syndrome are incompletely understood. This review aims to describe the association between soybean-derived isoflavone intake and the risk of metabolic syndrome development. We reviewed studies on soy isoflavones, particularly daidzein and genistein, and metabolic syndrome, using PubMed, ScienceDirect, and Web of Science. We describe the pathological characteristics of metabolic syndrome, including those contributing to multiple pathological conditions. Furthermore, we summarize the effects of soybean-derived daidzein and genistein on metabolic syndrome reported in human epidemiological studies and experiments using in vitro and in vivo models. In particular, we emphasize the role of soy isoflavones in metabolic syndrome-induced cardiovascular diseases. In conclusion, this review focuses on the potential of soy isoflavones to prevent metabolic syndrome by influencing the onset of hypertension, hyperglycemia, dyslipidemia, and arteriosclerosis and discusses the anti-inflammatory effects of isoflavones.
异黄酮主要存在于大豆中，是一类多酚类化合物，作为植物雌激素，对多种慢性疾病有有益作用。代谢综合征会增加肥胖症、高血压、高血糖和血脂异常等多种病理状态个体的动脉粥样硬化死亡风险。虽然大豆来源的异黄酮的健康益处已被广泛知晓，但它们对代谢综合征发病机制的有益作用尚不完全清楚。本综述旨在描述大豆来源的异黄酮摄入与代谢综合征发展风险之间的关系。我们检索了PubMed、ScienceDirect 和 Web of Science 上关于大豆异黄酮（特别是大豆苷元和染料木黄酮）和代谢综合征的研究，描述了代谢综合征的病理特征，包括导致多种病理状态的因素。此外，我们总结了在人类流行病学研究和体外及体内模型实验中报告的大豆来源的大豆苷元和染料木黄酮对代谢综合征的影响，特别强调了大豆异黄酮在代谢综合征相关心血管疾病中的作用。总之，本综述重点关注了大豆异黄酮通过影响高血压、高血糖、血脂异常和动脉粥样硬化的发生来预防代谢综合征的潜力，并讨论了异黄酮的抗炎作用。
