Dhakal Rajendra, Kim E S, Jo Yong-Hwa, Kim Sung-Soo, Kim Nam-Young
Department of Electronic Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Department of Electronic Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Med Eng Phys. 2017 Mar;41:55-62. doi: 10.1016/j.medengphy.2017.01.008. Epub 2017 Jan 31.
We present a concept for the characterization of micro-fabricated based resonator incorporating air-bridge metal-insulator-semiconductor (MIS) capacitor to continuously monitor an individual's state of glucose levels based on frequency variation. The investigation revealed that, the micro-resonator based on MIS capacitor holds considerable promise for implementation and recognition as a glucose sensor for human serum. The discrepancy in complex permittivity as a result of enhanced capacitor was achieved for the detection and determination of random glucose concentration levels using a unique variation of capacitor that indeed results in an adequate variation of the resonance frequency. Moreover, the design and development of micro-resonator with enhanced MIS capacitor generate a resolution of 112.38 × 10pF/mg/dl, minimum detectable glucose level of 7.45mg/dl, and a limit of quantification of 22.58mg/dl. Additionally, this unique approach offers long-term reliability for mediator-free glucose sensing with a relative standard deviation of less than 0.5%.
我们提出了一种基于微制造的谐振器的概念，该谐振器集成了气桥金属-绝缘体-半导体（MIS）电容器，以基于频率变化连续监测个体的血糖水平状态。研究表明，基于MIS电容器的微谐振器在作为人血清葡萄糖传感器的实现和识别方面具有很大的前景。通过使用独特的电容器变化，实现了由于电容器增强而导致的复介电常数差异，用于检测和测定随机血糖浓度水平，这确实导致了共振频率的充分变化。此外，具有增强型MIS电容器的微谐振器的设计和开发产生了112.38×10pF/mg/dl的分辨率、7.45mg/dl的最低可检测血糖水平和22.58mg/dl的定量限。此外，这种独特的方法为无介质葡萄糖传感提供了长期可靠性，相对标准偏差小于0.5%。
