Kozuka Junko, Uno Akira, Matsuda Hiroshi, Toyoshima Yoshiya, Hamano Shin-Ichiro
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan; Graduate School of Human and Social Sciences, Musashino University, Japan; Children's Development and Human Health Department, Saitama Children's Medical Center, Japan.
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
Brain Dev. 2017 Jun;39(6):493-505. doi: 10.1016/j.braindev.2017.01.002. Epub 2017 Jan 31.
This study aimed to investigate the relationship between the change of language symptoms and the change of regional cerebral blood flow (rCBF) in the recovery process of two children with acquired aphasia caused by infarctions from Moyamoya disease with an onset age of 8years.
We compared the results for the Standard Language Test of Aphasia (SLTA) with rCBF changes in 7 language regions in the left hemisphere and their homologous regions in the right hemisphere at 4 time points from 3weeks for up to 5years after the onset of aphasia, while controlling for the effect of age.
In both cases, strong correlations were seen within a hemisphere between adjacent regions or regions that are connected by neuronal fibers, and between some language regions in the left hemisphere and their homologous regions in the right hemisphere. Conversely, there were differences between the two cases in the time course of rCBF changes during their recovery process.
Consistent with previous studies, the current study suggested that both hemispheres were involved in the long-term recovery of language symptoms in children with acquired aphasia. We suggest that the differences between both cases during their recovery process might be influenced by the brain states before aphasia, by which hemisphere was affected, and by the timing of the surgical revascularization procedure. However, the changes were observed in the data obtained for rCBF with strong correlations with the changes in language performance, so it is possible that rCBF could be used as a biomarker for language symptom changes.
本研究旨在调查两名8岁起病的烟雾病梗死所致获得性失语儿童恢复过程中语言症状变化与局部脑血流量（rCBF）变化之间的关系。
我们比较了失语症标准语言测试（SLTA）的结果与失语症发病后3周直至5年的4个时间点上左半球7个语言区域及其右半球同源区域的rCBF变化，同时控制年龄的影响。
在这两个病例中，半球内相邻区域或由神经纤维连接的区域之间，以及左半球的一些语言区域与其右半球同源区域之间均呈现出强相关性。相反，在恢复过程中，两个病例的rCBF变化时间进程存在差异。
与先前研究一致，本研究表明，两个半球均参与了获得性失语儿童语言症状的长期恢复。我们认为，两个病例在恢复过程中的差异可能受失语症前的脑状态、受影响的半球以及手术血运重建程序的时机影响。然而，在获得的rCBF数据中观察到的变化与语言表现的变化具有强相关性，因此rCBF有可能作为语言症状变化的生物标志物。
